Association of VEGF-1499C -> T polymorphism with diabetic nephropathy in type 1 diabetes mellitus

Amy Jayne McKnight, Alexander Maxwell, Christopher Patterson, H.R. Brady, D.A. Savage

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is reported to be implicated in the development of diabetic nephropathy. We performed a case-control study to determine if VEGF-2578C -> A, VEGF-1499C -> T, and VEGF-635G -> C single-nucleotide polymorphisms (SNPs) in the VEGF gene are associated with predisposition to diabetic nephropathy in type I diabetes. Genomic DNA was obtained from Irish type I diabetic individuals with nephropathy (cases, n=242) and those without nephropathy (controls, n=301), in addition to 400 healthy control samples. These samples were genotyped for the three SNPs using TaqMan or Pyrosequencing technology. Chi-squared analyses revealed no significant differences in genotype or allele frequencies in cases versus controls for VEGF-2578C -> A (genotype, P=.58; allele, P=.52) and VEGF-635G -> C (genotype, P=.58; allele, P=.33). However, a positive association with diabetic nephropathy was observed for the VEGF-1499T allele in the Northern Ireland population (P
Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalJournal of diabetes and its complications
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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