Association Study of SNAP25 and Schizophrenia in Irish Family and Case-Control Samples

A.H. Fanous, Z. Zhao, E.J.C.G. Van Den Oord, B.S. Maher, D.L. Thiselton, S.E. Bergen, B. Wormley, T. Bigdeli, R.L. Amdur, Francis O'Neill, D. Walsh, K.S. Kendler, B.P. Riley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

SNAP25 occurs on chromosome 20p12.2, which has been linked to schizophrenia in some samples, and recently linked to latent classes of psychotic illness in our sample. SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and dendritic sprouting, and its expression may be decreased in schizophrenia. We genotyped 18 haplotype-tagging SNPs in SNAP25 in a sample of 270 Irish high-density families. Single marker and haplotype analyses were performed in FBAT and PDT. We adjusted for multiple testing by computing q values. Association was followed up in an independent sample of 657 cases and 411 controls. We tested for allelic effects on the clinical phenotype by using the method of sequential addition and 5 factor-derived scores of the OPCRIT. Nine of 18 SNPs had Pvalues
Original languageEnglish
Pages (from-to)663-674
Number of pages12
JournalAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume153B
Issue number2
DOIs
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Fanous, A. H., Zhao, Z., Van Den Oord, E. J. C. G., Maher, B. S., Thiselton, D. L., Bergen, S. E., Wormley, B., Bigdeli, T., Amdur, R. L., O'Neill, F., Walsh, D., Kendler, K. S., & Riley, B. P. (2010). Association Study of SNAP25 and Schizophrenia in Irish Family and Case-Control Samples. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 153B(2), 663-674. https://doi.org/10.1002/ajmg.b.31037