Associations between depression and cognition, mild cognitive impairment and dementia in persons with diabetes mellitus: A systematic review and meta-analysis

Yeng Yan Chow, Milou Verdonschot, Claire T McEvoy, Geeske Peeters

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)
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Abstract

AIMS: This systematic review aimed to examine whether persons with diabetes and depression had poorer cognition and higher dementia risk than persons with diabetes only. Moreover, the impact of timing, frequency of depressive episodes throughout life, and antidepressant treatment were examined.

METHODS: PubMed, Embase and PsycINFO were searched to obtain observational studies between August 2015 and June 2021 that examined the association between depression and cognition, mild cognitive impairment or dementia in people with diabetes. Studies published before August 2015 were retrieved from a previous systematic review. Findings were pooled using meta-analyses.

RESULTS: 10 out of 19 included articles were appropriate for the meta-analyses. Persons with diabetes and depression experienced greater declines in executive function (SMD = -0.39 (-0.69, -0.08)), language (SMD = -0.80 (-1.52, -0.09)), memory (SMD = -0.63 (-1.12, -0.14)) and overall cognition (SMD = -0.77 (-1.33, -0.20)), and greater dementia risk (HR = 1.82 (1.79, 1.85)) than persons with diabetes only. No significant differences were observed for complex attention. No studies examined the role of timing and frequency of depressive episodes and antidepressant treatment.

CONCLUSION: In persons with diabetes, depression is associated with worse cognition and higher dementia risk. The potential mitigating effect of antidepressant treatment remains unclear.

Original languageEnglish
Article number109227
JournalDiabetes Research and Clinical Practice
Volume185
Early online date02 Feb 2022
DOIs
Publication statusPublished - 01 Mar 2022

Bibliographical note

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords

  • Antidepressive Agents/therapeutic use
  • Cognition
  • Cognitive Dysfunction/complications
  • Dementia/epidemiology
  • Depression/complications
  • Diabetes Mellitus/epidemiology
  • Humans

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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