Associations between dietary amino acid intakes and blood concentration levels

Isabel Iguacel; Julie A Schmidt; Aurora Perez-Cornago; Heleen Van Puyvelde; Ruth Travis; Magdalena Stepien; Augustin Scalbert; Corinne Casagrande; Elisabete Weiderpass; Elio Riboli; Matthias B Schulze; Guri Skeie; Stina Bodén; Heiner Boeing; Amanda J Cross; Sophia Harlid; Torill Enget Jensen; José M Huerta; Verena Katzke; Tilman Kühn; Leila Lujan-Barroso; Giovanna Masala; Miguel Rodriguez-Barranco; Agnetha Linn Rostgaard-Hansen; Yvonne T van der Schouw; Roel Vermeulen; Giovanna Tagliabue; Anne Tjønneland; Morena Trevisan; Pietro Ferrari; Marc J Gunter; Inge Huybrechts

doi:10.1016/j.clnu.2021.04.036

Associations between dietary amino acid intakes and blood concentration levels

Isabel Iguacel, Julie A Schmidt, Aurora Perez-Cornago, Heleen Van Puyvelde, Ruth Travis, Magdalena Stepien, Augustin Scalbert, Corinne Casagrande, Elisabete Weiderpass, Elio Riboli, Matthias B Schulze, Guri Skeie, Stina Bodén, Heiner Boeing, Amanda J Cross, Sophia Harlid, Torill Enget Jensen, José M Huerta, Verena Katzke, Tilman KühnLeila Lujan-Barroso, Giovanna Masala, Miguel Rodriguez-Barranco, Agnetha Linn Rostgaard-Hansen, Yvonne T van der Schouw, Roel Vermeulen, Giovanna Tagliabue, Anne Tjønneland, Morena Trevisan, Pietro Ferrari, Marc J Gunter, Inge Huybrechts

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Abstract

BACKGROUND AND AIMS: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

METHODS: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.

RESULTS: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.

CONCLUSIONS: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.

Original language	English
Pages (from-to)	3772-3779
Number of pages	8
Journal	Clinical Nutrition
Volume	40
Issue number	6
Early online date	27 Apr 2021
DOIs	https://doi.org/10.1016/j.clnu.2021.04.036
Publication status	Published - 01 Jun 2021
Externally published	Yes

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Associations between dietary amino acid intakes and blood concentration levels
Copyright 2021 Elsevier. This manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
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Iguacel, I., Schmidt, J. A., Perez-Cornago, A., Van Puyvelde, H., Travis, R., Stepien, M., Scalbert, A., Casagrande, C., Weiderpass, E., Riboli, E., Schulze, M. B., Skeie, G., Bodén, S., Boeing, H., Cross, A. J., Harlid, S., Jensen, T. E., Huerta, J. M., Katzke, V., ... Huybrechts, I. (2021). Associations between dietary amino acid intakes and blood concentration levels. Clinical Nutrition, 40(6), 3772-3779. https://doi.org/10.1016/j.clnu.2021.04.036

Iguacel, Isabel ; Schmidt, Julie A ; Perez-Cornago, Aurora ; Van Puyvelde, Heleen ; Travis, Ruth ; Stepien, Magdalena ; Scalbert, Augustin ; Casagrande, Corinne ; Weiderpass, Elisabete ; Riboli, Elio ; Schulze, Matthias B ; Skeie, Guri ; Bodén, Stina ; Boeing, Heiner ; Cross, Amanda J ; Harlid, Sophia ; Jensen, Torill Enget ; Huerta, José M ; Katzke, Verena ; Kühn, Tilman ; Lujan-Barroso, Leila ; Masala, Giovanna ; Rodriguez-Barranco, Miguel ; Rostgaard-Hansen, Agnetha Linn ; van der Schouw, Yvonne T ; Vermeulen, Roel ; Tagliabue, Giovanna ; Tjønneland, Anne ; Trevisan, Morena ; Ferrari, Pietro ; Gunter, Marc J ; Huybrechts, Inge. / Associations between dietary amino acid intakes and blood concentration levels. In: Clinical Nutrition. 2021 ; Vol. 40, No. 6. pp. 3772-3779.

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title = "Associations between dietary amino acid intakes and blood concentration levels",

abstract = "BACKGROUND AND AIMS: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.RESULTS: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.CONCLUSIONS: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.",

author = "Isabel Iguacel and Schmidt, {Julie A} and Aurora Perez-Cornago and {Van Puyvelde}, Heleen and Ruth Travis and Magdalena Stepien and Augustin Scalbert and Corinne Casagrande and Elisabete Weiderpass and Elio Riboli and Schulze, {Matthias B} and Guri Skeie and Stina Bod{\'e}n and Heiner Boeing and Cross, {Amanda J} and Sophia Harlid and Jensen, {Torill Enget} and Huerta, {Jos{\'e} M} and Verena Katzke and Tilman K{\"u}hn and Leila Lujan-Barroso and Giovanna Masala and Miguel Rodriguez-Barranco and Rostgaard-Hansen, {Agnetha Linn} and {van der Schouw}, {Yvonne T} and Roel Vermeulen and Giovanna Tagliabue and Anne Tj{\o}nneland and Morena Trevisan and Pietro Ferrari and Gunter, {Marc J} and Inge Huybrechts",

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month = jun,

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doi = "10.1016/j.clnu.2021.04.036",

language = "English",

volume = "40",

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Iguacel, I, Schmidt, JA, Perez-Cornago, A, Van Puyvelde, H, Travis, R, Stepien, M, Scalbert, A, Casagrande, C, Weiderpass, E, Riboli, E, Schulze, MB, Skeie, G, Bodén, S, Boeing, H, Cross, AJ, Harlid, S, Jensen, TE, Huerta, JM, Katzke, V, Kühn, T, Lujan-Barroso, L, Masala, G, Rodriguez-Barranco, M, Rostgaard-Hansen, AL, van der Schouw, YT, Vermeulen, R, Tagliabue, G, Tjønneland, A, Trevisan, M, Ferrari, P, Gunter, MJ & Huybrechts, I 2021, 'Associations between dietary amino acid intakes and blood concentration levels', Clinical Nutrition, vol. 40, no. 6, pp. 3772-3779. https://doi.org/10.1016/j.clnu.2021.04.036

Associations between dietary amino acid intakes and blood concentration levels. / Iguacel, Isabel; Schmidt, Julie A; Perez-Cornago, Aurora; Van Puyvelde, Heleen; Travis, Ruth; Stepien, Magdalena; Scalbert, Augustin; Casagrande, Corinne; Weiderpass, Elisabete; Riboli, Elio; Schulze, Matthias B; Skeie, Guri; Bodén, Stina; Boeing, Heiner; Cross, Amanda J; Harlid, Sophia; Jensen, Torill Enget; Huerta, José M; Katzke, Verena; Kühn, Tilman; Lujan-Barroso, Leila; Masala, Giovanna; Rodriguez-Barranco, Miguel; Rostgaard-Hansen, Agnetha Linn; van der Schouw, Yvonne T; Vermeulen, Roel; Tagliabue, Giovanna; Tjønneland, Anne; Trevisan, Morena; Ferrari, Pietro; Gunter, Marc J; Huybrechts, Inge.

In: Clinical Nutrition, Vol. 40, No. 6, 01.06.2021, p. 3772-3779.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Associations between dietary amino acid intakes and blood concentration levels

AU - Iguacel, Isabel

AU - Schmidt, Julie A

AU - Perez-Cornago, Aurora

AU - Van Puyvelde, Heleen

AU - Travis, Ruth

AU - Stepien, Magdalena

AU - Scalbert, Augustin

AU - Casagrande, Corinne

AU - Weiderpass, Elisabete

AU - Riboli, Elio

AU - Schulze, Matthias B

AU - Skeie, Guri

AU - Bodén, Stina

AU - Boeing, Heiner

AU - Cross, Amanda J

AU - Harlid, Sophia

AU - Jensen, Torill Enget

AU - Huerta, José M

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Lujan-Barroso, Leila

AU - Masala, Giovanna

AU - Rodriguez-Barranco, Miguel

AU - Rostgaard-Hansen, Agnetha Linn

AU - van der Schouw, Yvonne T

AU - Vermeulen, Roel

AU - Tagliabue, Giovanna

AU - Tjønneland, Anne

AU - Trevisan, Morena

AU - Ferrari, Pietro

AU - Gunter, Marc J

AU - Huybrechts, Inge

PY - 2021/6/1

Y1 - 2021/6/1

N2 - BACKGROUND AND AIMS: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.RESULTS: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.CONCLUSIONS: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.

AB - BACKGROUND AND AIMS: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.RESULTS: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.CONCLUSIONS: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.

U2 - 10.1016/j.clnu.2021.04.036

DO - 10.1016/j.clnu.2021.04.036

M3 - Article

C2 - 34130023

VL - 40

SP - 3772

EP - 3779

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 6

ER -

Associations between dietary amino acid intakes and blood concentration levels

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