Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study

A. J. Yeates, E.M. McSorley, M.S. Mulhern, T. Spence, W. Crowe, K. Grzesik, S. W. Thurston, G.E. Watson, G.J. Myers, P.W. Davidson, C.F. Shamlaye, E. van Wijngaarden, J.J Strain

Research output: Contribution to journalArticle

Abstract

Problem
Markers of maternal inflammation may determine infant birth outcomes.

Method of Study
Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status.

Results
Neither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β= -0.058, P = 0.017) and birth length (β=-0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β=-0.057, P = 0.023) and IL-2 (β=0.073, P = 0.009) and the chemokine MCP-1 (β=0.067, P = 0.016) were predictive of a longer gestational age.

Conclusions
In our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy.
LanguageEnglish
Number of pages16
JournalJournal of Reproductive Immunology
Early online date23 Oct 2019
DOIs
Publication statusEarly online date - 23 Oct 2019

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Seychelles
Vascular Endothelial Growth Factor D
Child Development
Mothers
Parturition
Gestational Age
Inflammation
Interleukin-2
Pregnancy
Biomarkers
Linear Models
Interleukin-5
Maternal Age
Parity
Chemokines
Social Class
Interleukin-4
Interleukin-10
Pregnant Women
Interleukin-6

Cite this

Yeates, A. J. ; McSorley, E.M. ; Mulhern, M.S. ; Spence, T. ; Crowe, W. ; Grzesik, K. ; Thurston, S. W. ; Watson, G.E. ; Myers, G.J. ; Davidson, P.W. ; Shamlaye, C.F. ; van Wijngaarden, E. ; Strain, J.J. / Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study. In: Journal of Reproductive Immunology. 2019.
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title = "Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study",
abstract = "ProblemMarkers of maternal inflammation may determine infant birth outcomes.Method of StudyMaternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status.ResultsNeither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β= -0.058, P = 0.017) and birth length (β=-0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β=-0.057, P = 0.023) and IL-2 (β=0.073, P = 0.009) and the chemokine MCP-1 (β=0.067, P = 0.016) were predictive of a longer gestational age.ConclusionsIn our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy.",
author = "Yeates, {A. J.} and E.M. McSorley and M.S. Mulhern and T. Spence and W. Crowe and K. Grzesik and Thurston, {S. W.} and G.E. Watson and G.J. Myers and P.W. Davidson and C.F. Shamlaye and {van Wijngaarden}, E. and J.J Strain",
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Yeates, AJ, McSorley, EM, Mulhern, MS, Spence, T, Crowe, W, Grzesik, K, Thurston, SW, Watson, GE, Myers, GJ, Davidson, PW, Shamlaye, CF, van Wijngaarden, E & Strain, JJ 2019, 'Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study', Journal of Reproductive Immunology. https://doi.org/10.1016/j.jri.2019.102623

Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study. / Yeates, A. J.; McSorley, E.M.; Mulhern, M.S.; Spence, T.; Crowe, W.; Grzesik, K.; Thurston, S. W.; Watson, G.E.; Myers, G.J.; Davidson, P.W.; Shamlaye, C.F. ; van Wijngaarden, E. ; Strain, J.J.

In: Journal of Reproductive Immunology, 23.10.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study

AU - Yeates, A. J.

AU - McSorley, E.M.

AU - Mulhern, M.S.

AU - Spence, T.

AU - Crowe, W.

AU - Grzesik, K.

AU - Thurston, S. W.

AU - Watson, G.E.

AU - Myers, G.J.

AU - Davidson, P.W.

AU - Shamlaye, C.F.

AU - van Wijngaarden, E.

AU - Strain, J.J

PY - 2019/10/23

Y1 - 2019/10/23

N2 - ProblemMarkers of maternal inflammation may determine infant birth outcomes.Method of StudyMaternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status.ResultsNeither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β= -0.058, P = 0.017) and birth length (β=-0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β=-0.057, P = 0.023) and IL-2 (β=0.073, P = 0.009) and the chemokine MCP-1 (β=0.067, P = 0.016) were predictive of a longer gestational age.ConclusionsIn our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy.

AB - ProblemMarkers of maternal inflammation may determine infant birth outcomes.Method of StudyMaternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status.ResultsNeither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β= -0.058, P = 0.017) and birth length (β=-0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β=-0.057, P = 0.023) and IL-2 (β=0.073, P = 0.009) and the chemokine MCP-1 (β=0.067, P = 0.016) were predictive of a longer gestational age.ConclusionsIn our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy.

U2 - 10.1016/j.jri.2019.102623

DO - 10.1016/j.jri.2019.102623

M3 - Article

JO - Journal of Reproductive Immunology

T2 - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

SN - 0165-0378

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