ASYMMETRIC-SYNTHESIS OF S-(+)-4-AMINO-5-HEXYNOIC ACID

H MCALONAN, PJ STEVENSON, Paul Stevenson

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23 Citations (Scopus)

Abstract

4-Amino-5-hexynoic acid is efficiently synthesised in eight steps (overall yield 10%) from commercially available (S)-glutamic acid. The key step was conversion of an aldehyde to an acetylene using diethylmethydiazophosphonate.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalTetrahedron-Asymmetry
Volume6
Issue number1
Publication statusPublished - Jan 1995

Keywords

  • GABA
  • AMINOTRANSFERASE
  • INHIBITORS
  • DERIVATIVES
  • MECHANISM
  • REAGENT

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