ATR-dependent bystander effects in nontargeted cells

Susanne Burdak-Rothkamm*, Kai Rothkamm, Kevin M. Prise

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ionising radiation-induced effects in nontargeted bystander cells may play an important role in low-dose cancer risk. Here, we briefly review the experimental systems used for bystander studies, the initiation and intercellular transmission of bystander signals and response mechanisms in recipient cells. Recent evidence that implicates the histone 2A variant X (H2AX) and the deoxyribonucleic acid (DNA) damage kinase ataxia telangiectasia and Rad3-related (ATR) in bystander signalling is highlighted and the implications of bystander responses for human radiation protection are discussed.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalInternational Journal of Low Radiation
Volume5
Issue number1
DOIs
Publication statusPublished - 01 Jun 2008

Keywords

  • Ataxia telangiectasia and Rad3-related
  • ATR
  • Bystander signalling
  • DNA damage response
  • Gamma-H2AX
  • Low-dose risk assessment
  • Radiation-induced bystander effect

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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