Attention deficits in Alzheimer's disease and vascular dementia

Bernadette McGuinness*, Suzanne Barrett, David Craig, J. Lawson, Peter Passmore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

OBJECTIVE:

To compare the performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of information processing and attention.

METHOD:

Patients with AD (n=75) and VaD (n=46) were recruited from a memory clinic along with dementia-free participants (n=28). They underwent specific tests of attention from the Cognitive Drug Research battery, and pen and paper tests including Colour Trails A and B and Stroop. All patients had a CT brain scan that was independently scored for white-matter change/ischaemia.

RESULTS:

Attention was impaired in both AD and VaD patients. VaD patients had more impaired choice reaction times and were less accurate on a vigilance test measuring sustained attention. Deficits in selective and divided attention occurred in both patient groups and showed the strongest correlations with Mini Mental State Examination scores.

CONCLUSION:

This study demonstrates problems with the attentional network in mild-moderate AD and VaD. The authors propose that attention should be tested routinely in a memory clinic setting.
Original languageEnglish
Pages (from-to)157-159
Number of pages3
JournalJournal of neurology, neurosurgery, and psychiatry
Volume81
Issue number2
DOIs
Publication statusPublished - Feb 2010

Bibliographical note

This article has been cited 47 times. I was responsible for ethical approval, phenotyping of participants with Alzheimer's disease, carrying out neuropsychological tests, statistical analysis and writing the manuscript.

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

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