Abstract
Members of a large pedigree of Irish origin presenting with early onset Type I autosomal dominant retinitis pigmentosa (ADRP) have been typed for D3S47 (C17), a polymorphic marker from the long arm of chromosome 3. Significant, tight linkage of ADRP to D3S47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the ADRP gene (RP1) segregating in this pedigree to 3q.
Original language | English |
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Pages (from-to) | 619-22 |
Number of pages | 4 |
Journal | Genomics |
Volume | 5 |
Issue number | 3 |
Publication status | Published - Oct 1989 |
Keywords
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Female
- Genes, Dominant
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Male
- Pedigree
- Polymorphism, Genetic
- Recombination, Genetic
- Retinitis Pigmentosa