Axo-myelinic neurotransmission a novel mode of cell signalling in the central nervous system

Ileana Micu; Jason R Plemel; Andrew V Caprariello; Klaus-Armin Nave; Peter K Stys

doi:10.1038/nrn.2017.128

Axo-myelinic neurotransmission a novel mode of cell signalling in the central nervous system

Ileana Micu, Jason R Plemel, Andrew V Caprariello, Klaus-Armin Nave, Peter K Stys

Research output: Contribution to journal › Review article › peer-review

103 Citations (Scopus)

Abstract

It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte-myelin complex may in turn respond by providing metabolic support or alter subtle myelin properties to modulate action potential propagation. In this Opinion, we discuss what is known regarding the molecular physiology of this novel, synapse-like communication and speculate on potential roles in disease states including multiple sclerosis, schizophrenia and Alzheimer disease. An emerging appreciation of the contribution of white-matter perturbations to neurological dysfunction identifies the axo-myelinic synapse as a potential novel therapeutic target.

Original language	English
Pages (from-to)	49-58
Number of pages	10
Journal	Nature Reviews Neuroscience
Volume	19
Issue number	1
DOIs	https://doi.org/10.1038/nrn.2017.128
Publication status	Published - 14 Dec 2017
Externally published	Yes

Keywords

Myelin
Axons/physiology
Brain Diseases/physiopathology
Central Nervous System/physiology
Multiple Sclerosis
Models, Neurological
Myelin Sheath/physiology
Oligodendroglia/physiology
Synaptic Transmission/physiology

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title = "Axo-myelinic neurotransmission a novel mode of cell signalling in the central nervous system",

abstract = "It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte-myelin complex may in turn respond by providing metabolic support or alter subtle myelin properties to modulate action potential propagation. In this Opinion, we discuss what is known regarding the molecular physiology of this novel, synapse-like communication and speculate on potential roles in disease states including multiple sclerosis, schizophrenia and Alzheimer disease. An emerging appreciation of the contribution of white-matter perturbations to neurological dysfunction identifies the axo-myelinic synapse as a potential novel therapeutic target.",

keywords = "Myelin, Axons/physiology, Brain Diseases/physiopathology, Central Nervous System/physiology, Multiple Sclerosis, Models, Neurological, Myelin Sheath/physiology, Oligodendroglia/physiology, Synaptic Transmission/physiology",

author = "Ileana Micu and Plemel, {Jason R} and Caprariello, {Andrew V} and Klaus-Armin Nave and Stys, {Peter K}",

year = "2017",

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doi = "10.1038/nrn.2017.128",

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T1 - Axo-myelinic neurotransmission a novel mode of cell signalling in the central nervous system

AU - Micu, Ileana

AU - Plemel, Jason R

AU - Caprariello, Andrew V

AU - Nave, Klaus-Armin

AU - Stys, Peter K

PY - 2017/12/14

Y1 - 2017/12/14

N2 - It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte-myelin complex may in turn respond by providing metabolic support or alter subtle myelin properties to modulate action potential propagation. In this Opinion, we discuss what is known regarding the molecular physiology of this novel, synapse-like communication and speculate on potential roles in disease states including multiple sclerosis, schizophrenia and Alzheimer disease. An emerging appreciation of the contribution of white-matter perturbations to neurological dysfunction identifies the axo-myelinic synapse as a potential novel therapeutic target.

AB - It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte-myelin complex may in turn respond by providing metabolic support or alter subtle myelin properties to modulate action potential propagation. In this Opinion, we discuss what is known regarding the molecular physiology of this novel, synapse-like communication and speculate on potential roles in disease states including multiple sclerosis, schizophrenia and Alzheimer disease. An emerging appreciation of the contribution of white-matter perturbations to neurological dysfunction identifies the axo-myelinic synapse as a potential novel therapeutic target.

KW - Myelin

KW - Axons/physiology

KW - Brain Diseases/physiopathology

KW - Central Nervous System/physiology

KW - Multiple Sclerosis

KW - Models, Neurological

KW - Myelin Sheath/physiology

KW - Oligodendroglia/physiology

KW - Synaptic Transmission/physiology

U2 - 10.1038/nrn.2017.128

DO - 10.1038/nrn.2017.128

M3 - Review article

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EP - 58

JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

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ER -

Axo-myelinic neurotransmission a novel mode of cell signalling in the central nervous system

Abstract

Keywords

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