Aza-[4 + 2] cycloadditions employing catalytically derived N-acyliminium ions

Niamh J. Owen; Mark G. McLaughlin

doi:10.1039/D2OB01663J

Aza-[4 + 2] cycloadditions employing catalytically derived N-acyliminium ions

Niamh J. Owen, Mark G. McLaughlin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf2)2/nBu4NPF6 catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predominantly good yields.

Original language	English
Pages (from-to)	8209-8211
Journal	Organic & biomolecular chemistry
Volume	20
Issue number	42
Early online date	11 Oct 2022
DOIs	https://doi.org/10.1039/D2OB01663J
Publication status	Published - 14 Nov 2022
Externally published	Yes

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10.1039/D2OB01663JLicence: CC BY-NC

Aza-[4 + 2] cycloadditions employing catalytically derived N-acyliminium ions
Copyright 2022 the authors. This is an open access Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 868 KBLicence: CC BY-NC

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AB - Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf2)2/nBu4NPF6 catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predominantly good yields.

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Aza-[4 + 2] cycloadditions employing catalytically derived N-acyliminium ions

Abstract

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