Bacterial conversion of a host weapon into a nutritional signal

Miguel A. Valvano

doi:10.1016/j.jbc.2022.102600

Bacterial conversion of a host weapon into a nutritional signal

Miguel A. Valvano

School of Medicine, Dentistry and Biomedical Sciences

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Abstract

Bacteria engulfed by phagocytic cells must resist oxidation damage and adapt to cellular hypoxia, but the mechanisms involved in this process are not completely elucidated. Recent work by Kim et al. in the Journal of Biological Chemistry investigated how the intracellular pathogen Salmonella enterica activates gene expression required to counteract oxidative damage. The authors show that this bacterium utilizes host oxidative molecules to activate regulatory proteins that enhance the production of effector molecules, counteracting the host weapon NADPH oxidase and inducing a protective response.

Original language	English
Article number	102600
Journal	The Journal of Biological Chemistry
Volume	298
Issue number	11
DOIs	https://doi.org/10.1016/j.jbc.2022.102600
Publication status	Published - 01 Nov 2022

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10.1016/j.jbc.2022.102600Licence: CC BY

Bacterial conversion of a host weapon into a nutritional signal
Copyright 2022 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 363 KBLicence: CC BY

Cite this

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Bacterial conversion of a host weapon into a nutritional signal

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