BACTERIAL OXIDATION OF BENZOCYCLOALKENES TO YIELD MONOL, DIOL AND TRIOL METABOLITES

DR BOYD*, ND SHARMA, PJ STEVENSON, J CHIMA, DJ GRAY, H DALTON, Paul Stevenson

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Benzylic monooxygenation of benzocycloalkenes, 2-4, by enzymes in intact cultures of Pseudomonas putida UV4 yielded exclusively the [R] enantiomers, 6-8, and the derived ketones 10-12; by contrast, biotransformation of benzocyclobutene, 1, yielded both monooxygenation (5 and 9), dioxygenation (13, 14 and 15), and trioxygenation (16) products.

Original languageEnglish
Pages (from-to)3887-3890
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number31
Publication statusPublished - 29 Jul 1991

Keywords

  • BACTERIAL OXIDATION
  • PSEUDOMONAS-PUTIDA UV4
  • BENZOCYCLOALKENES
  • ALCOHOL AND KETONE METABOLITES
  • PSEUDOMONAS-PUTIDA
  • NAPHTHALENE
  • TOLUENE

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