Bacteriophages against Proteus mirabilis Biofilms

Cormac Rice; Chris J. Ganacias; ZhengHua Chai; Padrig B. Flynn; Brendan F. Gilmore; Brian V. Jones; Nicola Irwin; Leonid A. Kulakov; Timofey Skvortsov

Bacteriophages against Proteus mirabilis Biofilms

Cormac Rice, Chris J. Ganacias, ZhengHua Chai, Padrig B. Flynn, Brendan F. Gilmore, Brian V. Jones, Nicola Irwin, Leonid A. Kulakov, Timofey Skvortsov

Research output: Contribution to conference › Poster › peer-review

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Abstract

Proteus mirabilis is a Gram-negative, rod-shaped, opportunistically pathogenic bacterium, often found in the urinary tract. P. mirabilis strains are characterised by their ability to produce urease, which catalyses the hydrolysis of the urine’s urea into ammonia and carbon dioxide. The released ammonia increases the pH of the urine, promoting the formation and accumulation of struvite deposits which can in turn result in catheter blockages.
Bacteriophages are a unique type of virus that recognize a specific type of bacteria and then infect and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs.

Original language	English
Number of pages	1
Publication status	Published - 20 Sep 2019
Event	Eurobiofilms 2019 - Glasgow, United Kingdom Duration: 03 Sep 2019 → 06 Sep 2019 https://www.eurobiofilms2019.com/

Conference

Conference	Eurobiofilms 2019
Country/Territory	United Kingdom
City	Glasgow
Period	03/09/2019 → 06/09/2019
Internet address	https://www.eurobiofilms2019.com/

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Bacteriophages against Proteus Mirabilis Biofilms
© 2019 The Authors.
Other version, 1.05 MBLicence: Other

Novel bacteriophages and their derived proteins for the biocontrol of proteus and pseudomonas biofilms
Author: Rice, C., Dec 2022
Supervisor: Gilmore, B. (Supervisor), Skvortsov, T. (Supervisor) & Allen, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy

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title = "Bacteriophages against Proteus mirabilis Biofilms",

abstract = "Proteus mirabilis is a Gram-negative, rod-shaped, opportunistically pathogenic bacterium, often found in the urinary tract. P. mirabilis strains are characterised by their ability to produce urease, which catalyses the hydrolysis of the urine{\textquoteright}s urea into ammonia and carbon dioxide. The released ammonia increases the pH of the urine, promoting the formation and accumulation of struvite deposits which can in turn result in catheter blockages.Bacteriophages are a unique type of virus that recognize a specific type of bacteria and then infect and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs. ",

author = "Cormac Rice and Ganacias, {Chris J.} and ZhengHua Chai and Flynn, {Padrig B.} and Gilmore, {Brendan F.} and Jones, {Brian V.} and Nicola Irwin and Kulakov, {Leonid A.} and Timofey Skvortsov",

year = "2019",

month = sep,

day = "20",

language = "English",

note = "Eurobiofilms 2019 ; Conference date: 03-09-2019 Through 06-09-2019",

url = "https://www.eurobiofilms2019.com/",

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TY - CONF

T1 - Bacteriophages against Proteus mirabilis Biofilms

AU - Rice, Cormac

AU - Ganacias, Chris J.

AU - Chai, ZhengHua

AU - Flynn, Padrig B.

AU - Gilmore, Brendan F.

AU - Jones, Brian V.

AU - Irwin, Nicola

AU - Kulakov, Leonid A.

AU - Skvortsov, Timofey

PY - 2019/9/20

Y1 - 2019/9/20

N2 - Proteus mirabilis is a Gram-negative, rod-shaped, opportunistically pathogenic bacterium, often found in the urinary tract. P. mirabilis strains are characterised by their ability to produce urease, which catalyses the hydrolysis of the urine’s urea into ammonia and carbon dioxide. The released ammonia increases the pH of the urine, promoting the formation and accumulation of struvite deposits which can in turn result in catheter blockages.Bacteriophages are a unique type of virus that recognize a specific type of bacteria and then infect and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs.

AB - Proteus mirabilis is a Gram-negative, rod-shaped, opportunistically pathogenic bacterium, often found in the urinary tract. P. mirabilis strains are characterised by their ability to produce urease, which catalyses the hydrolysis of the urine’s urea into ammonia and carbon dioxide. The released ammonia increases the pH of the urine, promoting the formation and accumulation of struvite deposits which can in turn result in catheter blockages.Bacteriophages are a unique type of virus that recognize a specific type of bacteria and then infect and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs.

M3 - Poster

T2 - Eurobiofilms 2019

Y2 - 3 September 2019 through 6 September 2019

ER -

Bacteriophages against Proteus mirabilis Biofilms

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Student theses

Novel bacteriophages and their derived proteins for the biocontrol of proteus and pseudomonas biofilms

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