Bacteriophages against Proteus mirabilis Biofilms

Cormac Rice, Chris J. Ganacias, ZhengHua Chai, Padrig B. Flynn, Brendan F. Gilmore, Brian V. Jones, Nicola Irwin, Leonid A. Kulakov, Timofey Skvortsov

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Proteus mirabilis is a Gram-negative, rod-shaped, opportunistically pathogenic bacterium, often found in the urinary tract. P. mirabilis strains are characterised by their ability to produce urease, which catalyses the hydrolysis of the urine’s urea into ammonia and carbon dioxide. The released ammonia increases the pH of the urine, promoting the formation and accumulation of struvite deposits which can in turn result in catheter blockages.
Bacteriophages are a unique type of virus that recognize a specific type of bacteria and then infect and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs.
Original languageEnglish
Number of pages1
Publication statusPublished - 20 Sep 2019
EventEurobiofilms 2019 - Glasgow, United Kingdom
Duration: 03 Sep 201906 Sep 2019


ConferenceEurobiofilms 2019
Country/TerritoryUnited Kingdom
Internet address


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