Bacteriophages for Biofilm Eradication

Bacteriophages or phages are a unique type of virus that recognize a specific type of bacteria and then infect, replicate and kill the host via cell lysis. The application of phages and their enzymes for treating bacterial biofilms has recently gained significant interest due to a number of significant advantages compared to traditional antibiotics, including high specificity and efficacy, low immunogenicity and production costs.
Proteus mirabilis, Stenotrophomonas maltophilia and Pseudomonas aeruginosa are all clinically relevant microorganisms associated with biofilm formation and thus there is great difficulty treating such infections.
With the increasing number of multi-drug resistant strains being reported the time for novel antimicrobial agents is now and thus we propose the use of bacteriophages to treat the said bacterial species’ biofilms.