Baseline cardiovascular disease and risk of cardiac events following radical radiotherapy in NSCLC

Gerard Walls; David Johnston; Aidan Cole

doi:10.1016/S0169-5002(23)00565-2

Baseline cardiovascular disease and risk of cardiac events following radical radiotherapy in NSCLC

Gerard Walls
, David Johnston
, Aidan Cole

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

1600 patients had complete data. The median heart ratio was 1.308 (0.15 interquartile-range), ie manual contours are bigger than automatic contour. In clinical multivariable model 1, planning target volume, age, N-stage and performance status were associated with survival. The addition of the heart ratio in Model 2, together with an interaction term, makes the model perform significantly better. The heart volume ratio has a small protective effect, ie a larger delineated manual delineated heart is associated with a reduced hazard of death. The effect is likely weak as only a volumetric heart dose constraints were used for optimisation.
Conclusion
Variability in contouring can be used as a natural experiment to test the impact of heart sparing. Larger delineations including the base of the heart are associated with reduced mortality, suggesting the importance of sparing the base of the heart.

Original language	English
Pages (from-to)	S60
Number of pages	1
Journal	Lung Cancer
Volume	178
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/S0169-5002(23)00565-2
Publication status	Published - 01 Apr 2023

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title = "Baseline cardiovascular disease and risk of cardiac events following radical radiotherapy in NSCLC",

abstract = "1600 patients had complete data. The median heart ratio was 1.308 (0.15 interquartile-range), ie manual contours are bigger than automatic contour. In clinical multivariable model 1, planning target volume, age, N-stage and performance status were associated with survival. The addition of the heart ratio in Model 2, together with an interaction term, makes the model perform significantly better. The heart volume ratio has a small protective effect, ie a larger delineated manual delineated heart is associated with a reduced hazard of death. The effect is likely weak as only a volumetric heart dose constraints were used for optimisation. Conclusion Variability in contouring can be used as a natural experiment to test the impact of heart sparing. Larger delineations including the base of the heart are associated with reduced mortality, suggesting the importance of sparing the base of the heart.",

author = "Gerard Walls and David Johnston and Aidan Cole",

year = "2023",

month = apr,

day = "1",

doi = "10.1016/S0169-5002(23)00565-2",

language = "English",

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TY - JOUR

T1 - Baseline cardiovascular disease and risk of cardiac events following radical radiotherapy in NSCLC

AU - Walls, Gerard

AU - Johnston, David

AU - Cole, Aidan

PY - 2023/4/1

Y1 - 2023/4/1

N2 - 1600 patients had complete data. The median heart ratio was 1.308 (0.15 interquartile-range), ie manual contours are bigger than automatic contour. In clinical multivariable model 1, planning target volume, age, N-stage and performance status were associated with survival. The addition of the heart ratio in Model 2, together with an interaction term, makes the model perform significantly better. The heart volume ratio has a small protective effect, ie a larger delineated manual delineated heart is associated with a reduced hazard of death. The effect is likely weak as only a volumetric heart dose constraints were used for optimisation. Conclusion Variability in contouring can be used as a natural experiment to test the impact of heart sparing. Larger delineations including the base of the heart are associated with reduced mortality, suggesting the importance of sparing the base of the heart.

AB - 1600 patients had complete data. The median heart ratio was 1.308 (0.15 interquartile-range), ie manual contours are bigger than automatic contour. In clinical multivariable model 1, planning target volume, age, N-stage and performance status were associated with survival. The addition of the heart ratio in Model 2, together with an interaction term, makes the model perform significantly better. The heart volume ratio has a small protective effect, ie a larger delineated manual delineated heart is associated with a reduced hazard of death. The effect is likely weak as only a volumetric heart dose constraints were used for optimisation. Conclusion Variability in contouring can be used as a natural experiment to test the impact of heart sparing. Larger delineations including the base of the heart are associated with reduced mortality, suggesting the importance of sparing the base of the heart.

U2 - 10.1016/S0169-5002(23)00565-2

DO - 10.1016/S0169-5002(23)00565-2

M3 - Meeting abstract

SN - 0169-5002

VL - 178

SP - S60

JO - Lung Cancer

JF - Lung Cancer

IS - Supplement 1

ER -

Baseline cardiovascular disease and risk of cardiac events following radical radiotherapy in NSCLC

Abstract

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