beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics

Eric Amigues, Etaoin Armstrong, Marcela Dvorakova, Marie Migaud, Meilan Huang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
Original languageEnglish
Article numberPII 910024118
Pages (from-to)238-259
Number of pages22
JournalNucleosides Nucleotides & Nucleic Acids
Volume28
Issue number3
DOIs
Publication statusPublished - 2009

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