Biaryl polyamides as a new class of DNA quadruplex-binding ligands

K.M. Rahman, A.P. Reszka, M. Gunaratnam, Shozeb Haider, P.W. Howard, K.R. Fox, S. Neidle, D.E. Thurston

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
Original languageEnglish
Pages (from-to)4097-4099
Number of pages3
JournalChemical Communications
Volume27
Issue number27
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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