Biaryl polyamides as a new class of DNA quadruplex-binding ligands

K.M. Rahman; A.P. Reszka; M. Gunaratnam; Shozeb Haider; P.W. Howard; K.R. Fox; S. Neidle; D.E. Thurston

doi:10.1039/b902359c

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

K.M. Rahman, A.P. Reszka, M. Gunaratnam, Shozeb Haider, P.W. Howard, K.R. Fox, S. Neidle, D.E. Thurston

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

Original language	English
Pages (from-to)	4097-4099
Number of pages	3
Journal	Chemical Communications
Volume	27
Issue number	27
DOIs	https://doi.org/10.1039/b902359c
Publication status	Published - 2009

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b902359c

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title = "Biaryl polyamides as a new class of DNA quadruplex-binding ligands",

abstract = "We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.",

author = "K.M. Rahman and A.P. Reszka and M. Gunaratnam and Shozeb Haider and P.W. Howard and K.R. Fox and S. Neidle and D.E. Thurston",

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AU - Rahman, K.M.

AU - Reszka, A.P.

AU - Gunaratnam, M.

AU - Haider, Shozeb

AU - Howard, P.W.

AU - Fox, K.R.

AU - Neidle, S.

AU - Thurston, D.E.

PY - 2009

Y1 - 2009

N2 - We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

AB - We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

U2 - 10.1039/b902359c

DO - 10.1039/b902359c

M3 - Article

SN - 1359-7345

VL - 27

SP - 4097

EP - 4099

JO - Chemical Communications

JF - Chemical Communications

IS - 27

ER -

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

Abstract

ASJC Scopus subject areas

UN SDGs

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