Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Luping Wang, Mei Jia, Ruxiang Zhang, Giuseppe Casalino, Usha Chakravarthy, Yanling Wang

Research output: Contribution to journalArticlepeer-review


Background: To report a rare case of nasal natural killer/T (NK/T) cell lymphoma with bilateral intraocular and lung metastasis and to further describe the clinical features of intraocular manifestations.

Case presentation: A 54-year-old man presented with a 3-month history of left nasal congestion, and bilateral vision impairment of one week duration. Subsequent maxillary computed tomography (CT) and multiple biopsies confirmed the diagnosis of nasal NK/T-cell lymphoma. EBV-encoded small RNA (EBER) in situ hybridization revealed EBV infection. A comprehensive ophthalmic examination found lymphoma-associated retinopathy and choroidopathy, which presented as bilateral diverse patterns and retinal detachment. In addition, the chest CT showed multiple scattered nodules in both lungs, and soft-tissue mass in the left hilum with mediastinal and axillary lymphadenopathy. The condition of this patient deteriorated rapidly and he died shortly after diagnosis.

Conclusions: The rarity of secondary ocular NK/T-cell lymphoma makes it challenging to identify these tumors early. Both otolaryngologist and ophthalmologists should be aware of ocular involvement and other secondary manifestations of NK/T-cell lymphoma.
Original languageEnglish
JournalEuropean journal of ophthalmology
Early online date05 Jan 2022
Publication statusEarly online date - 05 Jan 2022


  • Ophthalmology
  • General Medicine


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