Bimanual co-ordination in Huntington's disease

Katherine Johnson, J.E. Bennett, N. Georgiou, J.L. Bradshaw, E. Chiu, R. Cunnington, R. Iansek

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The ability of Huntington's disease patients to co-ordinate their two hands with and without external cueing was investigated. Twelve Huntington's disease patients and sex- and age-matched controls performed a bimanual cranking task at two speeds (0.5 Hz, 1.5 Hz) and phase relationships (in-phase, anti-phase), with and without an external metronome cue. Data were sampled at 200 Hz, and raw displacement data for each hand, mean and standard deviation measures of the relative positions of the two hands and their velocities were then calculated. All participants could perform the in-phase movement, at both speeds; however, the Huntington's disease patients were more variable and less accurate than the control participants, particularly at the fast speed. While controls could perform the anti-phase movement, in which rotation of the cranks differed by 180 degrees at both speeds, Huntington's disease patients were unable to do so at either speed, reverting to the in-phase movement at the slow speed. An external metronome cue did not improve the performance of the Huntington's disease patients, which differentiated this group from patients suffering from Parkinson's disease. The Huntington's disease patients' inability to perform the anti-phase movement may be due to damage to the basal ganglia and its output regions.
Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalExperimental Brain Research
Volume134
Publication statusPublished - 2000

Fingerprint

Huntington Disease
Hand
Cues
Aptitude
Basal Ganglia
Parkinson Disease

Cite this

Johnson, K., Bennett, J. E., Georgiou, N., Bradshaw, J. L., Chiu, E., Cunnington, R., & Iansek, R. (2000). Bimanual co-ordination in Huntington's disease. Experimental Brain Research, 134, 483-489.
Johnson, Katherine ; Bennett, J.E. ; Georgiou, N. ; Bradshaw, J.L. ; Chiu, E. ; Cunnington, R. ; Iansek, R. / Bimanual co-ordination in Huntington's disease. In: Experimental Brain Research. 2000 ; Vol. 134. pp. 483-489.
@article{99e238b755764f439233c7a22e56cb54,
title = "Bimanual co-ordination in Huntington's disease",
abstract = "The ability of Huntington's disease patients to co-ordinate their two hands with and without external cueing was investigated. Twelve Huntington's disease patients and sex- and age-matched controls performed a bimanual cranking task at two speeds (0.5 Hz, 1.5 Hz) and phase relationships (in-phase, anti-phase), with and without an external metronome cue. Data were sampled at 200 Hz, and raw displacement data for each hand, mean and standard deviation measures of the relative positions of the two hands and their velocities were then calculated. All participants could perform the in-phase movement, at both speeds; however, the Huntington's disease patients were more variable and less accurate than the control participants, particularly at the fast speed. While controls could perform the anti-phase movement, in which rotation of the cranks differed by 180 degrees at both speeds, Huntington's disease patients were unable to do so at either speed, reverting to the in-phase movement at the slow speed. An external metronome cue did not improve the performance of the Huntington's disease patients, which differentiated this group from patients suffering from Parkinson's disease. The Huntington's disease patients' inability to perform the anti-phase movement may be due to damage to the basal ganglia and its output regions.",
author = "Katherine Johnson and J.E. Bennett and N. Georgiou and J.L. Bradshaw and E. Chiu and R. Cunnington and R. Iansek",
year = "2000",
language = "English",
volume = "134",
pages = "483--489",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",

}

Johnson, K, Bennett, JE, Georgiou, N, Bradshaw, JL, Chiu, E, Cunnington, R & Iansek, R 2000, 'Bimanual co-ordination in Huntington's disease', Experimental Brain Research, vol. 134, pp. 483-489.

Bimanual co-ordination in Huntington's disease. / Johnson, Katherine; Bennett, J.E.; Georgiou, N.; Bradshaw, J.L.; Chiu, E.; Cunnington, R.; Iansek, R.

In: Experimental Brain Research, Vol. 134, 2000, p. 483-489.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bimanual co-ordination in Huntington's disease

AU - Johnson, Katherine

AU - Bennett, J.E.

AU - Georgiou, N.

AU - Bradshaw, J.L.

AU - Chiu, E.

AU - Cunnington, R.

AU - Iansek, R.

PY - 2000

Y1 - 2000

N2 - The ability of Huntington's disease patients to co-ordinate their two hands with and without external cueing was investigated. Twelve Huntington's disease patients and sex- and age-matched controls performed a bimanual cranking task at two speeds (0.5 Hz, 1.5 Hz) and phase relationships (in-phase, anti-phase), with and without an external metronome cue. Data were sampled at 200 Hz, and raw displacement data for each hand, mean and standard deviation measures of the relative positions of the two hands and their velocities were then calculated. All participants could perform the in-phase movement, at both speeds; however, the Huntington's disease patients were more variable and less accurate than the control participants, particularly at the fast speed. While controls could perform the anti-phase movement, in which rotation of the cranks differed by 180 degrees at both speeds, Huntington's disease patients were unable to do so at either speed, reverting to the in-phase movement at the slow speed. An external metronome cue did not improve the performance of the Huntington's disease patients, which differentiated this group from patients suffering from Parkinson's disease. The Huntington's disease patients' inability to perform the anti-phase movement may be due to damage to the basal ganglia and its output regions.

AB - The ability of Huntington's disease patients to co-ordinate their two hands with and without external cueing was investigated. Twelve Huntington's disease patients and sex- and age-matched controls performed a bimanual cranking task at two speeds (0.5 Hz, 1.5 Hz) and phase relationships (in-phase, anti-phase), with and without an external metronome cue. Data were sampled at 200 Hz, and raw displacement data for each hand, mean and standard deviation measures of the relative positions of the two hands and their velocities were then calculated. All participants could perform the in-phase movement, at both speeds; however, the Huntington's disease patients were more variable and less accurate than the control participants, particularly at the fast speed. While controls could perform the anti-phase movement, in which rotation of the cranks differed by 180 degrees at both speeds, Huntington's disease patients were unable to do so at either speed, reverting to the in-phase movement at the slow speed. An external metronome cue did not improve the performance of the Huntington's disease patients, which differentiated this group from patients suffering from Parkinson's disease. The Huntington's disease patients' inability to perform the anti-phase movement may be due to damage to the basal ganglia and its output regions.

M3 - Article

VL - 134

SP - 483

EP - 489

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

ER -

Johnson K, Bennett JE, Georgiou N, Bradshaw JL, Chiu E, Cunnington R et al. Bimanual co-ordination in Huntington's disease. Experimental Brain Research. 2000;134:483-489.