Bioactive agrocomposite for tissue engineering and bone regeneration

Miguel Suffo; Celia Pérez-Muñoz; Daniel Goma-Jiménez; Carlos Revenga; Pablo Andrés-Cano; Miguel Ángel Cauqui-López

doi:10.3390/inventions9060123

Bioactive agrocomposite for tissue engineering and bone regeneration

Miguel Suffo
, Celia Pérez-Muñoz
, Daniel Goma-Jiménez
, Carlos Revenga
, Pablo Andrés-Cano
, Miguel Ángel Cauqui-López

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

39 Downloads (Pure)

Abstract

Background: This study describes a novel biomaterial consisting of a mixture of biphasic bioceramic obtained from waste generated by the sugar industry (Carbocal) and a medical-grade epoxy resin adhesive called LOCTITE® M31 CLTM. The objective was to demonstrate the possibility of coating non-bioactive and non-biodegradable metallic surfaces on implantable elements.

Methods: After preparation, the mixture was applied to the surfaces of hip prostheses composed of two distinct materials: polyetherimide and grade 5 titanium. In both cases, adhesion tests produced favourable results. Additionally, cell cultures were conducted using human foetal osteoblastic cell lines (hFOB 1.19).

Results: It was observed that the mixture did not affect the proliferation of bone cells. Conclusions: This composite material was found to promote the growth of bone cells, suggesting its potential for fostering bone tissue development.

Original language	English
Article number	123
Journal	Inventions
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/inventions9060123
Publication status	Published - 09 Dec 2024

Keywords

Bioactive agrocomposite
tissue engineering
bone regeneration

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10.3390/inventions9060123Licence: CC BY

Bioactive agrocomposite for tissue engineering and bone regeneration
Copyright 2024 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 3.89 MBLicence: CC BY

Cite this

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title = "Bioactive agrocomposite for tissue engineering and bone regeneration",

abstract = "Background: This study describes a novel biomaterial consisting of a mixture of biphasic bioceramic obtained from waste generated by the sugar industry (Carbocal) and a medical-grade epoxy resin adhesive called LOCTITE{\textregistered} M31 CLTM. The objective was to demonstrate the possibility of coating non-bioactive and non-biodegradable metallic surfaces on implantable elements. Methods: After preparation, the mixture was applied to the surfaces of hip prostheses composed of two distinct materials: polyetherimide and grade 5 titanium. In both cases, adhesion tests produced favourable results. Additionally, cell cultures were conducted using human foetal osteoblastic cell lines (hFOB 1.19). Results: It was observed that the mixture did not affect the proliferation of bone cells. Conclusions: This composite material was found to promote the growth of bone cells, suggesting its potential for fostering bone tissue development.",

keywords = "Bioactive agrocomposite, tissue engineering, bone regeneration",

author = "Miguel Suffo and Celia P{\'e}rez-Mu{\~n}oz and Daniel Goma-Jim{\'e}nez and Carlos Revenga and Pablo Andr{\'e}s-Cano and Cauqui-L{\'o}pez, \{Miguel {\'A}ngel\}",

year = "2024",

month = dec,

day = "9",

doi = "10.3390/inventions9060123",

language = "English",

volume = "9",

journal = "Inventions",

issn = "2411-5134",

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TY - JOUR

T1 - Bioactive agrocomposite for tissue engineering and bone regeneration

AU - Suffo, Miguel

AU - Pérez-Muñoz, Celia

AU - Goma-Jiménez, Daniel

AU - Revenga, Carlos

AU - Andrés-Cano, Pablo

AU - Cauqui-López, Miguel Ángel

PY - 2024/12/9

Y1 - 2024/12/9

N2 - Background: This study describes a novel biomaterial consisting of a mixture of biphasic bioceramic obtained from waste generated by the sugar industry (Carbocal) and a medical-grade epoxy resin adhesive called LOCTITE® M31 CLTM. The objective was to demonstrate the possibility of coating non-bioactive and non-biodegradable metallic surfaces on implantable elements. Methods: After preparation, the mixture was applied to the surfaces of hip prostheses composed of two distinct materials: polyetherimide and grade 5 titanium. In both cases, adhesion tests produced favourable results. Additionally, cell cultures were conducted using human foetal osteoblastic cell lines (hFOB 1.19). Results: It was observed that the mixture did not affect the proliferation of bone cells. Conclusions: This composite material was found to promote the growth of bone cells, suggesting its potential for fostering bone tissue development.

AB - Background: This study describes a novel biomaterial consisting of a mixture of biphasic bioceramic obtained from waste generated by the sugar industry (Carbocal) and a medical-grade epoxy resin adhesive called LOCTITE® M31 CLTM. The objective was to demonstrate the possibility of coating non-bioactive and non-biodegradable metallic surfaces on implantable elements. Methods: After preparation, the mixture was applied to the surfaces of hip prostheses composed of two distinct materials: polyetherimide and grade 5 titanium. In both cases, adhesion tests produced favourable results. Additionally, cell cultures were conducted using human foetal osteoblastic cell lines (hFOB 1.19). Results: It was observed that the mixture did not affect the proliferation of bone cells. Conclusions: This composite material was found to promote the growth of bone cells, suggesting its potential for fostering bone tissue development.

KW - Bioactive agrocomposite

KW - tissue engineering

KW - bone regeneration

U2 - 10.3390/inventions9060123

DO - 10.3390/inventions9060123

M3 - Article

SN - 2411-5134

VL - 9

JO - Inventions

JF - Inventions

IS - 6

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ER -

Bioactive agrocomposite for tissue engineering and bone regeneration

Abstract

Keywords

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