Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering

Jose Guillermo Torres-Rendon, Tim Femmer, Laura De Laporte, Thomas Tigges, Khoshrow Rahimi, Felix Gremse, Sara Zafarnia, Wiltrud Lederle, Shinsuke Ifuku, Matthias Wessling, John G. Hardy, Andreas Walther

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117 Citations (Scopus)
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Abstract

A sacrificial templating process using lithographically printed minimal surface structures allows complex de novo geometries of delicate hydrogel materials. The hydrogel scaffolds based on cellulose and chitin nanofibrils show differences in terms of attachment of human mesenchymal stem cells, and allow their differentiation into osteogenic outcomes. The approach here serves as a first example toward designer hydrogel scaffolds viable for biomimetic tissue engineering.
Original languageEnglish
Pages (from-to)2989-2995
Number of pages7
JournalAdvanced Materials
Volume27
Issue number19
Early online date02 Apr 2015
DOIs
Publication statusPublished - 2015

Keywords

  • stem cells
  • cellulose nanofibrils
  • chitin nanofibrils
  • 3D printing
  • hydrogel scaffolds

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Materials Science(all)
  • Biomaterials
  • Polymers and Plastics

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    Torres-Rendon, J. G., Femmer, T., De Laporte, L., Tigges, T., Rahimi, K., Gremse, F., Zafarnia, S., Lederle, W., Ifuku, S., Wessling, M., Hardy, J. G., & Walther, A. (2015). Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering. Advanced Materials, 27(19), 2989-2995. https://doi.org/10.1002/adma.201405873