Biochip platforms as functional genomics tools for drug discovery

Ivan Wick, Gary Hardiman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Improvements in DNA microarray technology have resulted in the generation of data on a scale that, for the first time, permits detailed scrutiny of the human genome. These data provide the foundation for understanding not only the connections between genes and the purpose of genes in the human genome, but also the molecular basis of genetic defects. These advances have the potential to significantly improve healthcare management by improving disease diagnosis and specifically targeting molecular therapy. Herein, the current state of the technology is reviewed, the commercial platforms used by the biopharmaceutical industry are compared and contrasted, and recent efforts in cross-platform data integration are explored.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalCurrent Opinion in Drug Discovery and Development
Volume8
Issue number3
Publication statusPublished - 01 May 2005
Externally publishedYes

Keywords

  • Biochips
  • Data integration
  • Gene expression
  • Microarrays
  • Platform

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

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