Biofilm formation by Bacillus subtilis: new insights into regulatory strategies and assembly mechanisms

Lynne S. Cairns, Laura Hobley, Nicola R. Stanley-Wall

Research output: Contribution to journalArticle

98 Citations (Scopus)
296 Downloads (Pure)

Abstract

Biofilm formation is a social behaviour that generates favourable conditions for sustained survival in the natural environment. For the Gram-positive bacterium Bacillus subtilis the process involves the differentiation of cell fate within an isogenic population and the production of communal goods that form the biofilm matrix. Here we review recent progress in understanding the regulatory pathways that control biofilm formation and highlight developments in understanding the composition, function and structure of the biofilm matrix.

Original languageEnglish
Pages (from-to)587-98
Number of pages12
JournalMolecular Microbiology
Volume93
Issue number4
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Bacillus subtilis
  • Bacterial Proteins
  • Biofilms
  • DNA, Bacterial
  • Extracellular Matrix
  • Gene Expression Regulation, Bacterial

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