Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

D. Doria*, K. F. Kakolee, S. Kar, S.K. Litt, F. Fiorini, H. Ahmed, S. Green, JC. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. M. Prise, G. Schettino, M. Zepf, M. Borghesi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. 

Original languageEnglish
Title of host publicationAIP Conference Proceedings: Light at Extreme Intensities 2011
EditorsKaroly Osvay, Peter Dombi, Jozsef Andras Fulop, Katalin Varju
PublisherAIP Publishing
Pages135-138
Number of pages4
Volume1462
ISBN (Print)978-0-7354-1066-4
DOIs
Publication statusPublished - 09 Jul 2012
EventConference on Light at Extreme Intensities 2011 - Szeged, Hungary
Duration: 14 Nov 201118 Nov 2011

Conference

ConferenceConference on Light at Extreme Intensities 2011
CountryHungary
CitySzeged
Period14/11/201118/11/2011

Cite this

Doria, D., Kakolee, K. F., Kar, S., Litt, S. K., Fiorini, F., Ahmed, H., Green, S., Jeynes, JC. G., Kavanagh, J., Kirby, D., Kirkby, K. J., Lewis, C. L., Merchant, M. J., Nersisyan, G., Prasad, R., Prise, K. M., Schettino, G., Zepf, M., & Borghesi, M. (2012). Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons. In K. Osvay, P. Dombi, J. A. Fulop, & K. Varju (Eds.), AIP Conference Proceedings: Light at Extreme Intensities 2011 (Vol. 1462, pp. 135-138). AIP Publishing. https://doi.org/10.1063/1.4736777