Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

D. Doria*, K. F. Kakolee, S. Kar, S.K. Litt, F. Fiorini, H. Ahmed, S. Green, JC. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. M. Prise, G. Schettino, M. Zepf, M. Borghesi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. 

Original languageEnglish
Title of host publicationAIP Conference Proceedings: Light at Extreme Intensities 2011
EditorsKaroly Osvay, Peter Dombi, Jozsef Andras Fulop, Katalin Varju
PublisherAIP Publishing
Number of pages4
ISBN (Print)978-0-7354-1066-4
Publication statusPublished - 09 Jul 2012
EventConference on Light at Extreme Intensities 2011 - Szeged, Hungary
Duration: 14 Nov 201118 Nov 2011


ConferenceConference on Light at Extreme Intensities 2011

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