Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

D. Doria; K. F. Kakolee; S. Kar; S.K. Litt; F. Fiorini; H. Ahmed; S. Green; JC. G. Jeynes; J. Kavanagh; D. Kirby; K. J. Kirkby; C. L. Lewis; M. J. Merchant; G. Nersisyan; R. Prasad; K. M. Prise; G. Schettino; M. Zepf; M. Borghesi

doi:10.1063/1.4736777

Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

D. Doria^*, K. F. Kakolee, S. Kar, S.K. Litt, F. Fiorini, H. Ahmed, S. Green, JC. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. M. Prise, G. Schettino, M. Zepf, M. Borghesi

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10⁹Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

Original language	English
Title of host publication	AIP Conference Proceedings: Light at Extreme Intensities 2011
Editors	Karoly Osvay, Peter Dombi, Jozsef Andras Fulop, Katalin Varju
Publisher	AIP Publishing
Pages	135-138
Number of pages	4
Volume	1462
ISBN (Print)	978-0-7354-1066-4
DOIs	https://doi.org/10.1063/1.4736777
Publication status	Published - 09 Jul 2012
Event	Conference on Light at Extreme Intensities 2011 - Szeged, Hungary Duration: 14 Nov 2011 → 18 Nov 2011

Conference

Conference	Conference on Light at Extreme Intensities 2011
Country/Territory	Hungary
City	Szeged
Period	14/11/2011 → 18/11/2011

Access to Document

10.1063/1.4736777

Cite this

Doria, D., Kakolee, K. F., Kar, S., Litt, S. K., Fiorini, F., Ahmed, H., Green, S., Jeynes, JC. G., Kavanagh, J., Kirby, D., Kirkby, K. J., Lewis, C. L., Merchant, M. J., Nersisyan, G., Prasad, R., Prise, K. M., Schettino, G., Zepf, M., & Borghesi, M. (2012). Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons. In K. Osvay, P. Dombi, J. A. Fulop, & K. Varju (Eds.), AIP Conference Proceedings: Light at Extreme Intensities 2011 (Vol. 1462, pp. 135-138). AIP Publishing. https://doi.org/10.1063/1.4736777

@inproceedings{c1d2e087101d462e87751f4322c3bd3d,

title = "Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons",

abstract = "The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ",

author = "D. Doria and Kakolee, {K. F.} and S. Kar and S.K. Litt and F. Fiorini and H. Ahmed and S. Green and Jeynes, {JC. G.} and J. Kavanagh and D. Kirby and Kirkby, {K. J.} and Lewis, {C. L.} and Merchant, {M. J.} and G. Nersisyan and R. Prasad and Prise, {K. M.} and G. Schettino and M. Zepf and M. Borghesi",

year = "2012",

month = jul,

day = "9",

doi = "10.1063/1.4736777",

language = "English",

isbn = "978-0-7354-1066-4",

volume = "1462",

pages = "135--138",

editor = "Karoly Osvay and Peter Dombi and Fulop, {Jozsef Andras} and Katalin Varju",

booktitle = "AIP Conference Proceedings: Light at Extreme Intensities 2011",

publisher = "AIP Publishing",

note = "Conference on Light at Extreme Intensities 2011 ; Conference date: 14-11-2011 Through 18-11-2011",

}

Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCG, Kavanagh, J, Kirby, D, Kirkby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M & Borghesi, M 2012, Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons. in K Osvay, P Dombi, JA Fulop & K Varju (eds), AIP Conference Proceedings: Light at Extreme Intensities 2011. vol. 1462, AIP Publishing, pp. 135-138, Conference on Light at Extreme Intensities 2011, Szeged, Hungary, 14/11/2011. https://doi.org/10.1063/1.4736777

Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons. / Doria, D.; Kakolee, K. F.; Kar, S. et al.
AIP Conference Proceedings: Light at Extreme Intensities 2011. ed. / Karoly Osvay; Peter Dombi; Jozsef Andras Fulop; Katalin Varju. Vol. 1462 AIP Publishing, 2012. p. 135-138.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

AU - Doria, D.

AU - Kakolee, K. F.

AU - Kar, S.

AU - Litt, S.K.

AU - Fiorini, F.

AU - Ahmed, H.

AU - Green, S.

AU - Jeynes, JC. G.

AU - Kavanagh, J.

AU - Kirby, D.

AU - Kirkby, K. J.

AU - Lewis, C. L.

AU - Merchant, M. J.

AU - Nersisyan, G.

AU - Prasad, R.

AU - Prise, K. M.

AU - Schettino, G.

AU - Zepf, M.

AU - Borghesi, M.

PY - 2012/7/9

Y1 - 2012/7/9

N2 - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

AB - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

U2 - 10.1063/1.4736777

DO - 10.1063/1.4736777

M3 - Conference contribution

SN - 978-0-7354-1066-4

VL - 1462

SP - 135

EP - 138

BT - AIP Conference Proceedings: Light at Extreme Intensities 2011

A2 - Osvay, Karoly

A2 - Dombi, Peter

A2 - Fulop, Jozsef Andras

A2 - Varju, Katalin

PB - AIP Publishing

T2 - Conference on Light at Extreme Intensities 2011

Y2 - 14 November 2011 through 18 November 2011

ER -

Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons

Abstract

Conference

Access to Document

Fingerprint

Cite this