Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D. Doria; K. F. Kakolee; S. Kar; S. K. Litt; F. Fiorini; H. Ahmed; S. Green; J. C. G. Jeynes; J. Kavanagh; D. Kirby; K. J. Kirby; C. L. Lewis; M. J. Merchant; G. Nersisyan; R. Prasad; K. M. Prise; G. Schettino; M. Zepf; M. Borghesi

doi:10.1063/1.3699063

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10⁹ Gy/s

D. Doria
, K. F. Kakolee
, S. Kar
, S. K. Litt
, F. Fiorini
, H. Ahmed
, S. Green
, J. C. G. Jeynes
, J. Kavanagh
, D. Kirby
, K. J. Kirby
, C. L. Lewis
, M. J. Merchant
, G. Nersisyan
, R. Prasad
, K. M. Prise
, G. Schettino
, M. Zepf
, M. Borghesi

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

609 Downloads (Pure)

Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

Original language	English
Article number	011209
Number of pages	6
Journal	AIP Advances
Volume	2
Issue number	1
DOIs	https://doi.org/10.1063/1.3699063
Publication status	Published - Mar 2012

ASJC Scopus subject areas

General Physics and Astronomy

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10.1063/1.3699063

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
Copyright 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License.
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Cite this

Doria, D., Kakolee, K. F., Kar, S., Litt, S. K., Fiorini, F., Ahmed, H., Green, S., Jeynes, J. C. G., Kavanagh, J., Kirby, D., Kirby, K. J., Lewis, C. L., Merchant, M. J., Nersisyan, G., Prasad, R., Prise, K. M., Schettino, G., Zepf, M., & Borghesi, M. (2012). Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10⁹ Gy/s. AIP Advances, 2(1), Article 011209. https://doi.org/10.1063/1.3699063

@article{0b29a8b532ce4138ae603430320f8a7d,

title = "Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s",

abstract = "The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10\% survival is estimated from a comparison with a 225 kVp X-ray source.",

author = "D. Doria and Kakolee, \{K. F.\} and S. Kar and Litt, \{S. K.\} and F. Fiorini and H. Ahmed and S. Green and Jeynes, \{J. C. G.\} and J. Kavanagh and D. Kirby and Kirby, \{K. J.\} and Lewis, \{C. L.\} and Merchant, \{M. J.\} and G. Nersisyan and R. Prasad and Prise, \{K. M.\} and G. Schettino and M. Zepf and M. Borghesi",

year = "2012",

month = mar,

doi = "10.1063/1.3699063",

language = "English",

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publisher = "American Institute of Physics",

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Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCG, Kavanagh, J, Kirby, D, Kirby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M & Borghesi, M 2012, 'Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10⁹ Gy/s', AIP Advances, vol. 2, no. 1, 011209. https://doi.org/10.1063/1.3699063

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T1 - Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

AU - Doria, D.

AU - Kakolee, K. F.

AU - Kar, S.

AU - Litt, S. K.

AU - Fiorini, F.

AU - Ahmed, H.

AU - Green, S.

AU - Jeynes, J. C. G.

AU - Kavanagh, J.

AU - Kirby, D.

AU - Kirby, K. J.

AU - Lewis, C. L.

AU - Merchant, M. J.

AU - Nersisyan, G.

AU - Prasad, R.

AU - Prise, K. M.

AU - Schettino, G.

AU - Zepf, M.

AU - Borghesi, M.

PY - 2012/3

Y1 - 2012/3

N2 - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

AB - The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

U2 - 10.1063/1.3699063

DO - 10.1063/1.3699063

M3 - Article

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JO - AIP Advances

JF - AIP Advances

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