Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Soraia Rosa, Chris Connolly, Giuseppe Schettino, Karl T. Butterworth, Kevin M. Prise

Research output: Contribution to journalArticle

60 Citations (Scopus)
238 Downloads (Pure)

Abstract

There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence in vitro supported by a limited amount of in vivo experiments, along with advances in mechanistic understanding, GNPs have not yet translated into the clinic. This may be due to disparity between predicted levels of radiosensitization based on physical action, observed biological response and an incomplete mechanistic understanding, alongside current experimental limitations. This paper provides a review of the current state of the field, highlighting the potential underlying biological mechanisms in GNP radiosensitization and examining the barriers to clinical translation.

Original languageEnglish
Number of pages25
JournalCancer Nanotechnology
Volume8
Issue number2
DOIs
Publication statusPublished - 02 Feb 2017

Keywords

  • Journal Article
  • Review

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