Biological therapies in the acute respiratory distress syndrome

Andrew James Boyle, James Joseph McNamee, Daniel Francis McAuley

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

INTRODUCTION: The acute respiratory distress syndrome (ARDS) is characterised by life-threatening respiratory failure requiring mechanical ventilation, and multiple organ failure. It has a mortality of up to 30 - 45% and causes a long-term reduction in quality of life for survivors, with only approximately 50% of survivors able to return to work 12 months after hospital discharge.

AREAS COVERED: In this review we discuss the complex pathophysiology of ARDS, describe the mechanistic pathways implicated in the development of ARDS and how these are currently being targeted with novel biological therapies. These include therapies targeted against inflammatory cytokines, mechanisms mediating increased alveolar permeability and disordered coagulation, as well as the potential of growth factors, gene therapy and mesenchymal stem cells.

EXPERT OPINION: Although understanding of the pathophysiology of ARDS has improved, to date there are no effective pharmacological interventions that target a specific mechanism, with the only potentially effective therapies to date aiming to limit ventilator-associated lung injury. However, we believe that through this improved mechanistic insight and better clinical trial design, there is cautious optimism for the future of biological therapies in ARDS, and expect current and future biological compounds to provide treatment options to clinicians managing this devastating condition.

Original languageEnglish
Pages (from-to)969-81
JournalExpert Opinion on Biological Therapy
Volume14
Issue number7
Early online date05 Apr 2014
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Angiogenesis Inhibitors/therapeutic use
  • Antibodies, Monoclonal, Humanized/therapeutic use
  • Bevacizumab
  • Biological Therapy/adverse effects
  • Cytokines/antagonists & inhibitors
  • Genetic Therapy
  • Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use
  • Humans
  • Inflammation/etiology
  • Mesenchymal Stem Cell Transplantation
  • Respiration, Artificial
  • Respiratory Distress Syndrome, Adult/complications
  • Thrombophilia/etiology
  • Ventilator-Induced Lung Injury/prevention & control

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