Biology of the schistosome lung-stage schistosomulum

G. N. Gobert*, M. Chai, D. P. McManus

*Corresponding author for this work

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune response with the parasite surface, (3) glucose uptake mechanisms, and (4) defining the transcriptional profiles of lung-stage schistosomula compared with other developmental stages using microarrays. The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical studies.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalParasitology
Volume134
Issue number4
DOIs
Publication statusPublished - 01 Apr 2007
Externally publishedYes

Keywords

  • Immune evasion
  • In vitro model
  • Lung schistosomula
  • Schistosome

ASJC Scopus subject areas

  • Immunology
  • Parasitology

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