Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain

Ricardo Calderon-Gonzalez, Hector Teran-Navarro, Jose Maria Marimon, Claudia Gonzalez-Rico, Jorge Calvo-Montes, Elisabet Frande-Cabanes, Miriam Alkorta-Gurrutxaga, Maria del Carmen Fariñas, Luis Martinez-Martinez, Emilio Perez-Trallero, Carmen Alvarez-Dominguez

Research output: Contribution to journalArticle

6 Citations (Scopus)
4 Downloads (Pure)

Abstract

Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1-22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1-22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.
Original languageEnglish
Article number541
Number of pages9
JournalFrontiers in immunology
Volume7
DOIs
Publication statusPublished - 29 Nov 2016
Externally publishedYes

Keywords

  • Listeriosis
  • Listeria
  • Zoonoses

Fingerprint Dive into the research topics of 'Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain'. Together they form a unique fingerprint.

  • Cite this

    Calderon-Gonzalez, R., Teran-Navarro, H., Marimon, J. M., Gonzalez-Rico, C., Calvo-Montes, J., Frande-Cabanes, E., Alkorta-Gurrutxaga, M., Fariñas, M. D. C., Martinez-Martinez, L., Perez-Trallero, E., & Alvarez-Dominguez, C. (2016). Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain. Frontiers in immunology, 7, [541]. https://doi.org/10.3389/fimmu.2016.00541