Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis

Laura Pletsch-Borba; Cora Watzinger; Renée Turzanski Fortner; Verena Katzke; Lukas Schwingshackl; Solomon A Sowah; Anika Hüsing; Theron Johnson; Marie-Luise Groß; Sandra González Maldonado; Michael Hoffmeister; Peter Bugert; Rudolf Kaaks; Mirja Grafetstätter; Tilman Kühn

doi:10.3390/jcm8122075

Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis

Laura Pletsch-Borba, Cora Watzinger, Renée Turzanski Fortner, Verena Katzke, Lukas Schwingshackl, Solomon A Sowah, Anika Hüsing, Theron Johnson, Marie-Luise Groß, Sandra González Maldonado, Michael Hoffmeister, Peter Bugert, Rudolf Kaaks, Mirja Grafetstätter, Tilman Kühn

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Abstract

Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC-Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding.

Original language	English
Journal	Journal of Clinical Medicine
Volume	8
Issue number	12
DOIs	https://doi.org/10.3390/jcm8122075
Publication status	Published - 27 Nov 2019
Externally published	Yes

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Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Pletsch-Borba, L., Watzinger, C., Turzanski Fortner, R., Katzke, V., Schwingshackl, L., Sowah, S. A., Hüsing, A., Johnson, T., Groß, M.-L., González Maldonado, S., Hoffmeister, M., Bugert, P., Kaaks, R., Grafetstätter, M., & Kühn, T. (2019). Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 8(12). https://doi.org/10.3390/jcm8122075

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title = "Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis",

abstract = "Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC-Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding.",

author = "Laura Pletsch-Borba and Cora Watzinger and {Turzanski Fortner}, Ren{\'e}e and Verena Katzke and Lukas Schwingshackl and Sowah, {Solomon A} and Anika H{\"u}sing and Theron Johnson and Marie-Luise Gro{\ss} and {Gonz{\'a}lez Maldonado}, Sandra and Michael Hoffmeister and Peter Bugert and Rudolf Kaaks and Mirja Grafetst{\"a}tter and Tilman K{\"u}hn",

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doi = "10.3390/jcm8122075",

language = "English",

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Pletsch-Borba, L, Watzinger, C, Turzanski Fortner, R, Katzke, V, Schwingshackl, L, Sowah, SA, Hüsing, A, Johnson, T, Groß, M-L, González Maldonado, S, Hoffmeister, M, Bugert, P, Kaaks, R, Grafetstätter, M & Kühn, T 2019, 'Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis', Journal of Clinical Medicine, vol. 8, no. 12. https://doi.org/10.3390/jcm8122075

TY - JOUR

T1 - Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis

AU - Pletsch-Borba, Laura

AU - Watzinger, Cora

AU - Turzanski Fortner, Renée

AU - Katzke, Verena

AU - Schwingshackl, Lukas

AU - Sowah, Solomon A

AU - Hüsing, Anika

AU - Johnson, Theron

AU - Groß, Marie-Luise

AU - González Maldonado, Sandra

AU - Hoffmeister, Michael

AU - Bugert, Peter

AU - Kaaks, Rudolf

AU - Grafetstätter, Mirja

AU - Kühn, Tilman

PY - 2019/11/27

Y1 - 2019/11/27

N2 - Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC-Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding.

AB - Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC-Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding.

U2 - 10.3390/jcm8122075

DO - 10.3390/jcm8122075

M3 - Review article

C2 - 31783601

SN - 2077-0383

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 12

ER -

Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis

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