Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study

Laura Pletsch-Borba; Mirja Grafetstätter; Anika Hüsing; Sandra González Maldonado; Manja Kloss; Marie-Luise Groß; Theron Johnson; Disorn Sookthai; Peter Bugert; Rudolf Kaaks; Tilman Kühn

doi:10.1038/s41598-018-38259-y

Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study

Laura Pletsch-Borba, Mirja Grafetstätter, Anika Hüsing, Sandra González Maldonado, Manja Kloss, Marie-Luise Groß, Theron Johnson, Disorn Sookthai, Peter Bugert, Rudolf Kaaks, Tilman Kühn

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Abstract

Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were associated with established cardiovascular risk factors, but not MI risk. The tested biomarkers may reflect pathophysiological alterations in cardiovascular disease development rather than constituting independent MI risk factors.

Original language	English
Pages (from-to)	3004
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-38259-y
Publication status	Published - 28 Feb 2019
Externally published	Yes

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Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.26 MBLicence: CC BY

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Pletsch-Borba, Laura ; Grafetstätter, Mirja ; Hüsing, Anika ; González Maldonado, Sandra ; Kloss, Manja ; Groß, Marie-Luise ; Johnson, Theron ; Sookthai, Disorn ; Bugert, Peter ; Kaaks, Rudolf ; Kühn, Tilman. / Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study. In: Scientific Reports. 2019 ; Vol. 9, No. 1. pp. 3004.

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abstract = "Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were associated with established cardiovascular risk factors, but not MI risk. The tested biomarkers may reflect pathophysiological alterations in cardiovascular disease development rather than constituting independent MI risk factors.",

author = "Laura Pletsch-Borba and Mirja Grafetst{\"a}tter and Anika H{\"u}sing and {Gonz{\'a}lez Maldonado}, Sandra and Manja Kloss and Marie-Luise Gro{\ss} and Theron Johnson and Disorn Sookthai and Peter Bugert and Rudolf Kaaks and Tilman K{\"u}hn",

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Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study. / Pletsch-Borba, Laura; Grafetstätter, Mirja; Hüsing, Anika; González Maldonado, Sandra; Kloss, Manja; Groß, Marie-Luise; Johnson, Theron; Sookthai, Disorn; Bugert, Peter; Kaaks, Rudolf; Kühn, Tilman.

In: Scientific Reports, Vol. 9, No. 1, 28.02.2019, p. 3004.

Research output: Contribution to journal › Article › peer-review

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T1 - Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study

AU - Pletsch-Borba, Laura

AU - Grafetstätter, Mirja

AU - Hüsing, Anika

AU - González Maldonado, Sandra

AU - Kloss, Manja

AU - Groß, Marie-Luise

AU - Johnson, Theron

AU - Sookthai, Disorn

AU - Bugert, Peter

AU - Kaaks, Rudolf

AU - Kühn, Tilman

PY - 2019/2/28

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N2 - Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were associated with established cardiovascular risk factors, but not MI risk. The tested biomarkers may reflect pathophysiological alterations in cardiovascular disease development rather than constituting independent MI risk factors.

AB - Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were associated with established cardiovascular risk factors, but not MI risk. The tested biomarkers may reflect pathophysiological alterations in cardiovascular disease development rather than constituting independent MI risk factors.

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DO - 10.1038/s41598-018-38259-y

M3 - Article

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SP - 3004

JO - Nature Scientific Reports

JF - Nature Scientific Reports

SN - 2045-2322

IS - 1

ER -

Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study

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