Biosynthesis and genetics of ADP-heptose

Miguel A. Valvano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Glycero-manno-heptose is a common component in the lipopolysaccharide (LPS) of many Gram-negative bacteria. Mutants deficient in the synthesis of glycero-manno-heptose are highly sensitive to hydrophobic compounds, and display reduced virulence, making these genes and their products potential targets for developing novel antimicrobials. To date, the biosynthesis of the heptosyl precursors for the inner core oligosaccharide of the LPS molecule is not completely characterized. In this work, the genes and enzyme functions involved in the various steps of the biosynthesis of ADP-L-glycero-D-manno-heptose are discussed, especially those involved in the intermediate steps.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
JournalJournal of Endotoxin Research
Volume5
Issue number1-2
DOIs
Publication statusPublished - 01 Jan 1999
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

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