Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

S. Sparapani; S. Bellini; M. Gunaratnam; Shozeb Haider; A. Andreani; M. Rambaldi; A. Locatelli; R. Morigi; M. Granaiola; L. Varoli; S. Burnelli; A. Leoni; S. Neidle

doi:10.1039/c0cc00020e

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

S. Sparapani, S. Bellini, M. Gunaratnam, Shozeb Haider, A. Andreani, M. Rambaldi, A. Locatelli, R. Morigi, M. Granaiola, L. Varoli, S. Burnelli, A. Leoni, S. Neidle

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.

Original language	English
Pages (from-to)	5680-5682
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	31
DOIs	https://doi.org/10.1039/c0cc00020e
Publication status	Published - 21 Aug 2010

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
General Chemistry

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10.1039/c0cc00020e

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title = "Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif",

abstract = "A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.",

author = "S. Sparapani and S. Bellini and M. Gunaratnam and Shozeb Haider and A. Andreani and M. Rambaldi and A. Locatelli and R. Morigi and M. Granaiola and L. Varoli and S. Burnelli and A. Leoni and S. Neidle",

year = "2010",

month = aug,

day = "21",

doi = "10.1039/c0cc00020e",

language = "English",

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journal = "Chemical Communications",

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T1 - Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

AU - Sparapani, S.

AU - Bellini, S.

AU - Gunaratnam, M.

AU - Haider, Shozeb

AU - Andreani, A.

AU - Rambaldi, M.

AU - Locatelli, A.

AU - Morigi, R.

AU - Granaiola, M.

AU - Varoli, L.

AU - Burnelli, S.

AU - Leoni, A.

AU - Neidle, S.

PY - 2010/8/21

Y1 - 2010/8/21

N2 - A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.

AB - A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.

U2 - 10.1039/c0cc00020e

DO - 10.1039/c0cc00020e

M3 - Article

SN - 1359-7345

VL - 46

SP - 5680

EP - 5682

JO - Chemical Communications

JF - Chemical Communications

IS - 31

ER -

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

Abstract

ASJC Scopus subject areas

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