Blood pressure and TNF-α act synergistically to increase leucocyte CD11b adhesion molecule expression in the BELFAST study: implications for better blood pressure control in ageing

I Maeve Rea, Susan E McNerlan, Denis H Alexander, Michelle E Armstrong

Research output: Contribution to journalArticle

6 Citations (Scopus)
181 Downloads (Pure)

Abstract

Hypertension, a key risk factor for stroke, cardiovascular disease and dementia, is associated with chronic vascular inflammation, and although poorly understood, putative mechanisms include proinflammatory responses induced by mechanical stretching, with cytokine release and associated upregulated expression of adhesion molecules. Because blood pressure increases with age, we measured baseline and tumour necrosis alpha (TNF-a)-stimulated CD11b/CD18 adhesion molecule expression on leucocytes to assess any association between the two. In 38 subjects (mean age 85 years), consecutively enrolled from Belfast Elderly Longitudinal Free-Living Aging Study (BELFAST), baseline and TNF-a-stimulated CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure >120 mmHg (p=0.05) and for lymphocytes, with diastolic blood pressure >80 mmHg (p<0.05).These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-a, and suggest mechanistic reasons why better hypertension control is important. 

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalAGE
Volume35
Issue number1
Early online date16 Nov 2011
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Blood pressure
  • TNF-α
  • Leucocyte adhesion
  • CD11b/18
  • Ageing
  • BELFAST study

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing

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