Blood type gene locus has no influence on ACE association with Alzheimer's disease

Anne Braae; Christopher Medway; Minerva  Carrasquillo; Steven  Younkin; Alzheimer's Research UK (ARUK) Consortium; Patrick G Kehoe; Kevin Morgan; Peter Passmore; David Craig; Janet Johnston; Bernadette McGuinness

doi:10.1016/j.neurobiolaging.2015.01.013

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Anne Braae, Christopher Medway, Minerva Carrasquillo, Steven Younkin, Alzheimer's Research UK (ARUK) Consortium, Patrick G Kehoe, Kevin Morgan, Peter Passmore, David Craig, Janet Johnston, Bernadette McGuinness

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

Original language	English
Pages (from-to)	1767.e1-1767.e2
Journal	Neurobiology of Aging
Volume	36
Issue number	4
Early online date	22 Jan 2015
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.01.013
Publication status	Published - 01 Apr 2015

Keywords

ABO blood group
Alzheimer's disease
Angiotensin-converting enzyme
Genome-wide association study

Access to Document

10.1016/j.neurobiolaging.2015.01.013Licence: Unspecified

http://www.mendeley.com/research/blood-type-gene-locus-influence-ace-association-alzheimers-disease

Cite this

Braae, A., Medway, C., Carrasquillo, M., Younkin, S., Alzheimer's Research UK (ARUK) Consortium, Kehoe, P. G., Morgan, K., Passmore, P., Craig, D., Johnston, J., & McGuinness, B. (2015). Blood type gene locus has no influence on ACE association with Alzheimer's disease. Neurobiology of Aging, 36(4), 1767.e1-1767.e2. https://doi.org/10.1016/j.neurobiolaging.2015.01.013

@article{e190ca7c3dee46e097308749ab3f1250,

title = "Blood type gene locus has no influence on ACE association with Alzheimer's disease",

abstract = "The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.",

keywords = "ABO blood group, Alzheimer's disease, Angiotensin-converting enzyme, Genome-wide association study",

author = "Anne Braae and Christopher Medway and Minerva Carrasquillo and Steven Younkin and {Alzheimer's Research UK (ARUK) Consortium} and Kehoe, {Patrick G} and Kevin Morgan and Peter Passmore and David Craig and Janet Johnston and Bernadette McGuinness and Stephen Todd and Reinhard Heun and Heike K{\"o}lsch and Vardy, {Emma R L C} and Hooper, {Nigel M} and Mann, {David M.} and Stuart Pickering-Brown and Barber, {Imelda S.} and James Lowe and Smith, {A David} and Gordon Wilcock and Donald Warden and Clive Holmes",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.neurobiolaging.2015.01.013",

language = "English",

volume = "36",

pages = "1767.e1--1767.e2",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "4",

}

Braae, A, Medway, C, Carrasquillo, M, Younkin, S, Alzheimer's Research UK (ARUK) Consortium, Kehoe, PG, Morgan, K, Passmore, P, Craig, D, Johnston, J & McGuinness, B 2015, 'Blood type gene locus has no influence on ACE association with Alzheimer's disease', Neurobiology of Aging, vol. 36, no. 4, pp. 1767.e1-1767.e2. https://doi.org/10.1016/j.neurobiolaging.2015.01.013

TY - JOUR

T1 - Blood type gene locus has no influence on ACE association with Alzheimer's disease

AU - Braae, Anne

AU - Medway, Christopher

AU - Carrasquillo, Minerva

AU - Younkin, Steven

AU - Alzheimer's Research UK (ARUK) Consortium

AU - Kehoe, Patrick G

AU - Morgan, Kevin

AU - Passmore, Peter

AU - Craig, David

AU - Johnston, Janet

AU - McGuinness, Bernadette

AU - Todd, Stephen

AU - Heun, Reinhard

AU - Kölsch, Heike

AU - Vardy, Emma R L C

AU - Hooper, Nigel M

AU - Mann, David M.

AU - Pickering-Brown, Stuart

AU - Barber, Imelda S.

AU - Lowe, James

AU - Smith, A David

AU - Wilcock, Gordon

AU - Warden, Donald

AU - Holmes, Clive

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

AB - The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

KW - ABO blood group

KW - Alzheimer's disease

KW - Angiotensin-converting enzyme

KW - Genome-wide association study

U2 - 10.1016/j.neurobiolaging.2015.01.013

DO - 10.1016/j.neurobiolaging.2015.01.013

M3 - Article

C2 - 25681990

SN - 0197-4580

VL - 36

SP - 1767.e1-1767.e2

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this