BMP signalling: agony and antagony in the family

Derek P. Brazil*, Rachel H. Church, Satnam Surae, Catherine Godson, Finian Martin

*Corresponding author for this work

Research output: Contribution to journalLiterature review

148 Citations (Scopus)
541 Downloads (Pure)

Abstract

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

Original languageEnglish
Pages (from-to)249-264
Number of pages16
JournalTrends in Cell Biology
Volume25
Issue number5
Early online date12 Jan 2015
DOIs
Publication statusPublished - May 2015

Keywords

  • bone morphogenetic proteins
  • antagonist
  • miRNA
  • Gremlin
  • disease
  • BONE MORPHOGENETIC PROTEIN
  • GROWTH-FACTOR-BETA
  • TO-MESENCHYMAL TRANSITION
  • PULMONARY ARTERIAL-HYPERTENSION
  • SKELETAL-MUSCLE DIFFERENTIATION
  • KIELIN/CHORDIN-LIKE PROTEIN
  • GREMLIN-MEDIATED DECREASE
  • EMBRYONIC STEM-CELLS
  • TGF-BETA
  • RENAL FIBROSIS

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