Abstract
Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.
| Original language | English |
|---|---|
| Pages (from-to) | 249-264 |
| Number of pages | 16 |
| Journal | Trends in Cell Biology |
| Volume | 25 |
| Issue number | 5 |
| Early online date | 12 Jan 2015 |
| DOIs | |
| Publication status | Published - May 2015 |
Keywords
- bone morphogenetic proteins
- antagonist
- miRNA
- Gremlin
- disease
- BONE MORPHOGENETIC PROTEIN
- GROWTH-FACTOR-BETA
- TO-MESENCHYMAL TRANSITION
- PULMONARY ARTERIAL-HYPERTENSION
- SKELETAL-MUSCLE DIFFERENTIATION
- KIELIN/CHORDIN-LIKE PROTEIN
- GREMLIN-MEDIATED DECREASE
- EMBRYONIC STEM-CELLS
- TGF-BETA
- RENAL FIBROSIS
Access to Document
- BMP signalling Agony and Antagony in the family
2014 Elsevier Ltd. All rights reserved. This article has a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.