BMP signalling: agony and antagony in the family

Derek P. Brazil; Rachel H. Church; Satnam Surae; Catherine Godson; Finian Martin

doi:10.1016/j.tcb.2014.12.004

BMP signalling: agony and antagony in the family

Derek P. Brazil^*
, Rachel H. Church
, Satnam Surae
, Catherine Godson
, Finian Martin

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

275 Citations (Scopus)

1752 Downloads (Pure)

Abstract

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

Original language	English
Pages (from-to)	249-264
Number of pages	16
Journal	Trends in Cell Biology
Volume	25
Issue number	5
Early online date	12 Jan 2015
DOIs	https://doi.org/10.1016/j.tcb.2014.12.004
Publication status	Published - May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

bone morphogenetic proteins
antagonist
miRNA
Gremlin
disease
BONE MORPHOGENETIC PROTEIN
GROWTH-FACTOR-BETA
TO-MESENCHYMAL TRANSITION
PULMONARY ARTERIAL-HYPERTENSION
SKELETAL-MUSCLE DIFFERENTIATION
KIELIN/CHORDIN-LIKE PROTEIN
GREMLIN-MEDIATED DECREASE
EMBRYONIC STEM-CELLS
TGF-BETA
RENAL FIBROSIS

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10.1016/j.tcb.2014.12.004

BMP signalling Agony and Antagony in the family
2014 Elsevier Ltd. All rights reserved. This article has a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Accepted author manuscript, 862 KB

Cite this

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title = "BMP signalling: agony and antagony in the family",

abstract = "Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.",

keywords = "bone morphogenetic proteins, antagonist, miRNA, Gremlin, disease, BONE MORPHOGENETIC PROTEIN, GROWTH-FACTOR-BETA, TO-MESENCHYMAL TRANSITION, PULMONARY ARTERIAL-HYPERTENSION, SKELETAL-MUSCLE DIFFERENTIATION, KIELIN/CHORDIN-LIKE PROTEIN, GREMLIN-MEDIATED DECREASE, EMBRYONIC STEM-CELLS, TGF-BETA, RENAL FIBROSIS",

author = "Brazil, \{Derek P.\} and Church, \{Rachel H.\} and Satnam Surae and Catherine Godson and Finian Martin",

year = "2015",

month = may,

doi = "10.1016/j.tcb.2014.12.004",

language = "English",

volume = "25",

pages = "249--264",

journal = "Trends in Cell Biology",

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T1 - BMP signalling: agony and antagony in the family

AU - Brazil, Derek P.

AU - Church, Rachel H.

AU - Surae, Satnam

AU - Godson, Catherine

AU - Martin, Finian

PY - 2015/5

Y1 - 2015/5

N2 - Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

AB - Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

KW - bone morphogenetic proteins

KW - antagonist

KW - miRNA

KW - Gremlin

KW - disease

KW - BONE MORPHOGENETIC PROTEIN

KW - GROWTH-FACTOR-BETA

KW - TO-MESENCHYMAL TRANSITION

KW - PULMONARY ARTERIAL-HYPERTENSION

KW - SKELETAL-MUSCLE DIFFERENTIATION

KW - KIELIN/CHORDIN-LIKE PROTEIN

KW - GREMLIN-MEDIATED DECREASE

KW - EMBRYONIC STEM-CELLS

KW - TGF-BETA

KW - RENAL FIBROSIS

U2 - 10.1016/j.tcb.2014.12.004

DO - 10.1016/j.tcb.2014.12.004

M3 - Literature review

SN - 0962-8924

VL - 25

SP - 249

EP - 264

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -

BMP signalling: agony and antagony in the family

Abstract

UN SDGs

Keywords

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