Bone growth into a ceramic-filled defect around an implant. The response to transforming growth factor β1

S. A. Clarke, R. A. Brooks*, P. T.H. Lee, N. Rushton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Synthetic bone substitutes provide an alternative to autograft but do not give equivalent clinical results. Their performance may be enhanced by adding osteogenic growth factors. In this study, TGFβ1 was absorbed on to a carrier of β tricalcium phosphate and Gelfoam® and used to fill a defect around a tibial implant in a rat model of revision arthoplasty. We added 0.0, 0.02 μg, 0.1 μg or 1.0 μg of TGFβ1 to the carrier and then implanted it around an hydroxyapatite-coated stainless-steel pin in the proximal tibia of rats. The tibiae were harvested at three, six or 26 weeks and the amount of bone formation and ceramic resorption were assessed. TGFβ1 had no effect on the amount of bone in the defect, the amount of fluorescent label incorporated or the rate of mineral apposition. The growth factor did not significantly affect the amount of βTCP remaining in the tissue at any of the time points.

Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalJournal of Bone and Joint Surgery - Series B
Volume86
Issue number1
DOIs
Publication statusPublished - Jan 2004
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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