Botulinum toxin A for the treatment of keloids

G G Gauglitz, D Bureik, Y Dombrowski, T Pavicic, T Ruzicka, J Schauber

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity. Unfortunately, most therapeutic approaches remain clinically unsatisfactory. Recently, injections with botulinum toxin A (BTA) were proposed for the treatment of established keloids in a clinical trial. In this study, we aimed to verify the effects of intralesional BTA for the treatment of therapy-resistant keloids using objective measurements. In addition, the underlying molecular mechanisms were investigated using cultured keloid-derived fibroblasts.
Original languageEnglish
Pages (from-to)313-8
Number of pages6
JournalSkin pharmacology and physiology
Volume25
Issue number6
DOIs
Publication statusPublished - 2012

Bibliographical note

Copyright © 2012 S. Karger AG, Basel.

Keywords

  • Actins
  • Botulinum Toxins, Type A
  • Cell Proliferation
  • Collagen
  • Female
  • Fibroblasts
  • Fibronectins
  • Humans
  • Injections, Intralesional
  • Keloid
  • Laminin
  • Male
  • Transforming Growth Factor beta

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