Bovine serum transferrin concentration during acute infection with Haemophilus somnus

J. McNair*, C. Elliott, D. G. Bryson, D. P. Mackie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


A novel, competitive immunoassay based on time-resolved fluorimetry was developed, and used to measure the serum concentration of bovine transferrin during acute Haemophilus somnus pneumonia. Upper and lower limits of normality were established using serum from healthy cattle (3.72-1.37mg mL-1). Following experimental infection with Haemophilus somnus, transferrin concentration was depressed in all calves but recovered to pre-infection levels in groups of calves which had either no lesions, or mild lesions at necropsy between 5 and 6 days after infection. In a third group, which developed extensive lesions, the transferrin concentration remained depressed. Transferrin levels remained within the normal range for all calves during the experimental period. Those calves which had low transferrin concentrations pre-infection, developed extensive lung lesions following experimental infection with Haemophilus somnus.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalVeterinary Journal
Issue number3
Publication statusPublished - 01 Jan 1998


  • Bovine transferrin
  • Competitive immunoassay
  • Haemophilus somnus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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