Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.

J. Zhou; A.J. Bjourson; D.J.M. Coulter; Tianbao Chen; Christopher Shaw; M. O’Rourke; David Hirst; Y. Zhang; P.F. Rao; S. McClean

doi:10.1016/j.peptides.2007.01.014

Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.

J. Zhou, A.J. Bjourson, D.J.M. Coulter, Tianbao Chen, Christopher Shaw, M. O’Rourke, David Hirst, Y. Zhang, P.F. Rao, S. McClean

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Multiple bradykinin-related peptides including a novel bradykinin structural variant, (Val1)-bradykinin, have been identified from the defensive skin secretion of Guenther's frog, Hylarana guentheri by a tandem mass spectrometry method. Subsequently, four different preprobradykinin cDNAs, which encoded multiple bradykinin copies and its structural variants, were consistently cloned from a skin derived cDNA library. These preprobradykinin cDNAs showed little structural similarity with mammalian kininogens and the kininogens from the skin of toads, but have regions that are highly conserved in the kininogens from another ranid frog, Odorrana schmackeri. Alignment of these preprobradykinins revealed that preprobradykinin 1, 2 and 3 may derive from a single gene by alternative exon splicing.

Original language	English
Pages (from-to)	781-789
Number of pages	9
Journal	Peptides
Volume	28 (4)
Issue number	4
DOIs	https://doi.org/10.1016/j.peptides.2007.01.014
Publication status	Published - Apr 2007

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2007.01.014

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Zhou, J., Bjourson, A. J., Coulter, D. J. M., Chen, T., Shaw, C., O’Rourke, M., Hirst, D., Zhang, Y., Rao, P. F., & McClean, S. (2007). Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors. Peptides, 28 (4)(4), 781-789. https://doi.org/10.1016/j.peptides.2007.01.014

Zhou, J. ; Bjourson, A.J. ; Coulter, D.J.M. ; Chen, Tianbao ; Shaw, Christopher ; O’Rourke, M. ; Hirst, David ; Zhang, Y. ; Rao, P.F. ; McClean, S. / Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors. In: Peptides. 2007 ; Vol. 28 (4), No. 4. pp. 781-789.

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title = "Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.",

abstract = "Multiple bradykinin-related peptides including a novel bradykinin structural variant, (Val1)-bradykinin, have been identified from the defensive skin secretion of Guenther's frog, Hylarana guentheri by a tandem mass spectrometry method. Subsequently, four different preprobradykinin cDNAs, which encoded multiple bradykinin copies and its structural variants, were consistently cloned from a skin derived cDNA library. These preprobradykinin cDNAs showed little structural similarity with mammalian kininogens and the kininogens from the skin of toads, but have regions that are highly conserved in the kininogens from another ranid frog, Odorrana schmackeri. Alignment of these preprobradykinins revealed that preprobradykinin 1, 2 and 3 may derive from a single gene by alternative exon splicing.",

author = "J. Zhou and A.J. Bjourson and D.J.M. Coulter and Tianbao Chen and Christopher Shaw and M. O{\textquoteright}Rourke and David Hirst and Y. Zhang and P.F. Rao and S. McClean",

year = "2007",

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doi = "10.1016/j.peptides.2007.01.014",

language = "English",

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Zhou, J, Bjourson, AJ, Coulter, DJM, Chen, T, Shaw, C, O’Rourke, M, Hirst, D, Zhang, Y, Rao, PF & McClean, S 2007, 'Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.', Peptides, vol. 28 (4), no. 4, pp. 781-789. https://doi.org/10.1016/j.peptides.2007.01.014

Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors. / Zhou, J.; Bjourson, A.J.; Coulter, D.J.M.; Chen, Tianbao; Shaw, Christopher; O’Rourke, M.; Hirst, David; Zhang, Y.; Rao, P.F.; McClean, S.

In: Peptides, Vol. 28 (4), No. 4, 04.2007, p. 781-789.

Research output: Contribution to journal › Article › peer-review

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AU - Coulter, D.J.M.

AU - Chen, Tianbao

AU - Shaw, Christopher

AU - O’Rourke, M.

AU - Hirst, David

AU - Zhang, Y.

AU - Rao, P.F.

AU - McClean, S.

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Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.

Abstract

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