Bradykinin-related peptides, including a novel structural variant, (Val1)-bradykinin, from the skin secretion of Guenther's frog, Hylarana guentheri and their molecular precursors.

J. Zhou, A.J. Bjourson, D.J.M. Coulter, Tianbao Chen, Christopher Shaw, M. O’Rourke, David Hirst, Y. Zhang, P.F. Rao, S. McClean

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Multiple bradykinin-related peptides including a novel bradykinin structural variant, (Val1)-bradykinin, have been identified from the defensive skin secretion of Guenther's frog, Hylarana guentheri by a tandem mass spectrometry method. Subsequently, four different preprobradykinin cDNAs, which encoded multiple bradykinin copies and its structural variants, were consistently cloned from a skin derived cDNA library. These preprobradykinin cDNAs showed little structural similarity with mammalian kininogens and the kininogens from the skin of toads, but have regions that are highly conserved in the kininogens from another ranid frog, Odorrana schmackeri. Alignment of these preprobradykinins revealed that preprobradykinin 1, 2 and 3 may derive from a single gene by alternative exon splicing.
Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalPeptides
Volume28 (4)
Issue number4
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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