TY - JOUR
T1 - BRCA1, a potential biomarker in the treatment of breast cancer
AU - James, Colin
AU - O'Brien, Jennifer
AU - Mullan, Paul
AU - Johnston, Patrick
AU - Harkin, Paul
PY - 2007/2
Y1 - 2007/2
N2 - To date, estrogen receptor, progestogen receptor, and HER2/neu represent molecular biomarkers currently used in routine clinical practice to aid treatment decisions. Over the last few years, a large body of preclinical and retrospective clinical data has accumulated that suggests that BRCA1 mutation functions as a novel predictive marker of response to chemotherapy. This article reviews the role of BRCA1 as a predictive marker of chemotherapy response in breast cancer and examines the link between BRCA1 deficiency and the basal-like phenotype. Search strategy. Data for this article were identified through MEDLINE and PubMed searches for published reports using the terms BRCA1, breast cancer, basal-like, chemotherapy, prognosis, and predictive markers. In some cases, due to the restriction of space, readers are referred to review articles to allow further reading. Only articles published in English were included.
AB - To date, estrogen receptor, progestogen receptor, and HER2/neu represent molecular biomarkers currently used in routine clinical practice to aid treatment decisions. Over the last few years, a large body of preclinical and retrospective clinical data has accumulated that suggests that BRCA1 mutation functions as a novel predictive marker of response to chemotherapy. This article reviews the role of BRCA1 as a predictive marker of chemotherapy response in breast cancer and examines the link between BRCA1 deficiency and the basal-like phenotype. Search strategy. Data for this article were identified through MEDLINE and PubMed searches for published reports using the terms BRCA1, breast cancer, basal-like, chemotherapy, prognosis, and predictive markers. In some cases, due to the restriction of space, readers are referred to review articles to allow further reading. Only articles published in English were included.
UR - http://www.scopus.com/inward/record.url?scp=33847035558&partnerID=8YFLogxK
U2 - 10.1634/theoncologist.12-2-142
DO - 10.1634/theoncologist.12-2-142
M3 - Article
C2 - 17296808
SN - 1083-7159
VL - 12
SP - 142
EP - 150
JO - The Oncologist
JF - The Oncologist
IS - 2
ER -