Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment

Kienan Savage*, D. Paul Harkin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage. These proteins function in a number of cellular pathways in order to maintain genomic stability including DNA damage signaling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodeling, transcriptional regulation and apoptosis. This chapter will discuss the functions of these proteins and how they relate to tumour development, and therapy.

Original languageEnglish
Title of host publicationThe DNA Damage Response: Implications on Cancer Formation and Treatment
PublisherSpringer
Pages415-443
Number of pages29
ISBN (Print)9789048125609
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Savage, K., & Harkin, D. P. (2009). Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment. In The DNA Damage Response: Implications on Cancer Formation and Treatment (pp. 415-443). Springer. https://doi.org/10.1007/978-90-481-2561-6_18