Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment

Kienan Savage; D. Paul Harkin

doi:10.1007/978-90-481-2561-6_18

Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment

Kienan Savage^*, D. Paul Harkin

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage. These proteins function in a number of cellular pathways in order to maintain genomic stability including DNA damage signaling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodeling, transcriptional regulation and apoptosis. This chapter will discuss the functions of these proteins and how they relate to tumour development, and therapy.

Original language	English
Title of host publication	The DNA Damage Response: Implications on Cancer Formation and Treatment
Publisher	Springer
Pages	415-443
Number of pages	29
ISBN (Print)	9789048125609
DOIs	https://doi.org/10.1007/978-90-481-2561-6_18
Publication status	Published - 2009

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-90-481-2561-6_18

Cite this

@inbook{a7d5780b4dbe4deeacbbc0470d189e6e,

title = "Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment",

abstract = "BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage. These proteins function in a number of cellular pathways in order to maintain genomic stability including DNA damage signaling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodeling, transcriptional regulation and apoptosis. This chapter will discuss the functions of these proteins and how they relate to tumour development, and therapy.",

author = "Kienan Savage and Harkin, {D. Paul}",

year = "2009",

doi = "10.1007/978-90-481-2561-6_18",

language = "English",

isbn = "9789048125609",

pages = "415--443",

booktitle = "The DNA Damage Response: Implications on Cancer Formation and Treatment",

publisher = "Springer",

}

TY - CHAP

T1 - Brca1 and brca2

T2 - Role in the DNA damage response, cancer formation and treatment

AU - Savage, Kienan

AU - Harkin, D. Paul

PY - 2009

Y1 - 2009

N2 - BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage. These proteins function in a number of cellular pathways in order to maintain genomic stability including DNA damage signaling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodeling, transcriptional regulation and apoptosis. This chapter will discuss the functions of these proteins and how they relate to tumour development, and therapy.

AB - BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage. These proteins function in a number of cellular pathways in order to maintain genomic stability including DNA damage signaling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodeling, transcriptional regulation and apoptosis. This chapter will discuss the functions of these proteins and how they relate to tumour development, and therapy.

UR - http://www.scopus.com/inward/record.url?scp=83755165693&partnerID=8YFLogxK

U2 - 10.1007/978-90-481-2561-6_18

DO - 10.1007/978-90-481-2561-6_18

M3 - Chapter

AN - SCOPUS:83755165693

SN - 9789048125609

SP - 415

EP - 443

BT - The DNA Damage Response: Implications on Cancer Formation and Treatment

PB - Springer

ER -

Brca1 and brca2: Role in the DNA damage response, cancer formation and treatment

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this