BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma

James P Beirne; Jennifer Quinn; Perry Maxwell; Steve E Kalloger; Jessica McAlpine; C Blake Gilks; Ian J G Harley; W Glenn McCluggage

doi:10.1097/IGC.0b013e3182798188

BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma

James P Beirne, Jennifer Quinn, Perry Maxwell, Steve E Kalloger, Jessica McAlpine, C Blake Gilks, Ian J G Harley, W Glenn McCluggage

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

OBJECTIVES: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). METHODS: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival. RESULTS: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater (P = 0.0023). CONCLUSIONS: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Volume	23
Issue number	1
DOIs	https://doi.org/10.1097/IGC.0b013e3182798188 https://doi.org/10.1097/IGC.0b013e3182798188
Publication status	Published - Jan 2013

ASJC Scopus subject areas

Obstetrics and Gynaecology
Oncology

Access to Document

10.1097/IGC.0b013e3182798188Licence: Unspecified
10.1097/IGC.0b013e3182798188

Cite this

Beirne, J. P., Quinn, J., Maxwell, P., Kalloger, S. E., McAlpine, J., Gilks, C. B., Harley, I. J. G., & McCluggage, W. G. (2013). BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 23(1), 113-118. https://doi.org/10.1097/IGC.0b013e3182798188, https://doi.org/10.1097/IGC.0b013e3182798188

@article{7bde160fa2fd4b00a6771b6d66b76122,

title = "BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma",

abstract = "OBJECTIVES: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). METHODS: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival. RESULTS: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater (P = 0.0023). CONCLUSIONS: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.",

author = "Beirne, {James P} and Jennifer Quinn and Perry Maxwell and Kalloger, {Steve E} and Jessica McAlpine and Gilks, {C Blake} and Harley, {Ian J G} and McCluggage, {W Glenn}",

year = "2013",

month = jan,

doi = "10.1097/IGC.0b013e3182798188",

language = "English",

volume = "23",

pages = "113--118",

journal = "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",

issn = "1525-1438",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

Beirne, JP, Quinn, J, Maxwell, P, Kalloger, SE, McAlpine, J, Gilks, CB, Harley, IJG & McCluggage, WG 2013, 'BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma', International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, vol. 23, no. 1, pp. 113-118. https://doi.org/10.1097/IGC.0b013e3182798188, https://doi.org/10.1097/IGC.0b013e3182798188

BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma. / Beirne, James P; Quinn, Jennifer; Maxwell, Perry et al.
In: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 23, No. 1, 01.2013, p. 113-118.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma

AU - Beirne, James P

AU - Quinn, Jennifer

AU - Maxwell, Perry

AU - Kalloger, Steve E

AU - McAlpine, Jessica

AU - Gilks, C Blake

AU - Harley, Ian J G

AU - McCluggage, W Glenn

PY - 2013/1

Y1 - 2013/1

N2 - OBJECTIVES: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). METHODS: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival. RESULTS: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater (P = 0.0023). CONCLUSIONS: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.

AB - OBJECTIVES: The objective of this study was to investigate the relationship between BRCA1 protein expression, as determined by immunohistochemistry, and clinical outcome in uterine serous carcinoma (USC). METHODS: A tissue microarray containing duplicate cores of 73 cases of USC was immunohistochemically stained with mouse anti-BRCA1 (Ab-1) mouse monoclonal (MS110) antibody. The cores were scored in a semiquantitative manner evaluating both the distribution and intensity of nuclear staining. BRCA1 protein expression was correlated with progression-free survival. RESULTS: Seventy-two of 73 cases were assessable, and there was a statistically significant decreased progression-free survival for those cases exhibiting tumor cell nuclei staining of 76% or greater (P = 0.0023). CONCLUSIONS: Our study illustrates that a low level of BRCA1 protein expression is a favorable prognostic indicator in USC, similar to what is observed in high-grade serous ovarian carcinoma. Further studies should focus on the BRCA1 status of USCs at a molecular level and also investigate whether BRCA1 protein expression is associated with response to chemotherapy in USC.

UR - http://europepmc.org/abstract/med/23221734

U2 - 10.1097/IGC.0b013e3182798188

DO - 10.1097/IGC.0b013e3182798188

M3 - Article

C2 - 23221734

SN - 1525-1438

VL - 23

SP - 113

EP - 118

JO - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

IS - 1

ER -

BRCA1 Immunohistochemical Staining as a Prognostic Indicator in Uterine Serous Carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this