Brd4-independence in ground state pluripotency

Yaser Atlasi, Hendrik G Stunnenberg

Research output: Contribution to journalArticle

Abstract

Brd4, a reader of histone acetylation, is a transcriptional co-activator implicated in the maintenance of embryonic stem cells (ESCs). A study now shows that Brd4 is dispensable in mouse ESCs maintained in ground state pluripotency, and that cooperative activity of Tet1/2 and ESC-specific transcription factors compensates for its loss.
Original languageEnglish
Pages (from-to)513-515
Number of pages3
JournalNature Cell Biology
Volume20
Issue number5
DOIs
Publication statusPublished - May 2018
Externally publishedYes

Keywords

  • Embryonic Stem Cells
  • Nuclear Proteins
  • Pluripotent Stem Cells
  • Transcription Factors

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