Brd4, a reader of histone acetylation, is a transcriptional co-activator implicated in the maintenance of embryonic stem cells (ESCs). A study now shows that Brd4 is dispensable in mouse ESCs maintained in ground state pluripotency, and that cooperative activity of Tet1/2 and ESC-specific transcription factors compensates for its loss.
- Embryonic Stem Cells
- Nuclear Proteins
- Pluripotent Stem Cells
- Transcription Factors
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- School of Medicine, Dentistry and Biomedical Sciences - Vice-Chancellor Illuminate Fellow
- Patrick G Johnston Centre for Cancer Research