Brevinin-1GHd, A Novel Hylarana guentheri Skin Secretion-Derived Brevinin-1 Type Peptide with Antimicrobial and Anticancer Therapeutic Potential

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Abstract

Host-defence antimicrobial peptides (AMPs) from amphibians are usually considered as one of the most promising next-generation antibiotics because of their excellent antimicrobial properties and low cytotoxicity. In this study, one novel Brevinin-1 type peptide, Brevinin-1GHd, was isolated and characterized from the skin secretion of the frog, Hylarana guentheri. Brevinin-1GHd was found to possess a wide range of antimicrobial activity through penetrating the bacterial membrane within a short time while showing low hemolysis at bactericidal concentrations, even against the resistant strains. It also inhibited and eradicated biofilms which are thought to be closely related to the rise in resistance. Meanwhile, Brevinin-1GHd exhibited wide-spectrum anti-proliferation activity toward human cancer lines. Taken together, these results indicate that Brevinin-1GHd with its excellent antimicrobial and anticancer activities, is a promising candidate for a novel antibiotic agent, and study of its structure-activity relationships also provided a rational template for further research and peptide analog design.
Original languageEnglish
Article numberBSR20200019
Number of pages15
JournalBioscience Reports
Volume40
Issue number5
Early online date29 Apr 2020
DOIs
Publication statusPublished - 14 May 2020

Keywords

  • Brevinin-1GHd; anti-proliferation; antimicrobial peptides (AMPs); biofilms; resistant strains

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