Buccal absorption of enalapril and lisinopril

James McElnay, T.A. Al-Furaih, Carmel Hughes, Michael Scott, Stuart Elborn, D.P. Nicholls

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Objective: The buccal absorption of captopril does not exhibit the classical pH/partition hypothesis, suggesting that mechanisms other than passive diffusion are involved in its absorption; animal studies have suggested that a peptide carrier-mediated transport system may be responsible for its absorption. The present study evaluated the effects of pH on octanol partitioning, and on the buccal absorption of enalapril and lisinopril, using in vitro techniques and buccal partitioning in human volunteer subjects.
Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalEuropean Journal of Clinical Pharmacology
Volume54
Issue number8
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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