Abstract
Phorbol myristate acetate (PMA) was shown to be highly mitogenic for bursal lymphocytes (optimal concentration 2 μg/ml). Groups of 1-day-old chickens were inoculated with infectious bursal disease virus (IBDV, vaccine or virulent strains). Seven days after infection bursae were removed and the proliferation response of the bursal lymphocytes to PMA was determined. A significant reduction in the proliferation response was observed in the IBDV-inoculated birds. The results confirm that PMA is mitogenic for bursal lymphocytes and also demonstrate the usefulness of this in vitro assay for investigations into immune dysfunction in the bursa of Fabricius.
| Original language | English |
|---|---|
| Pages (from-to) | 301-303 |
| Number of pages | 3 |
| Journal | Avian Pathology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1999 |
| Externally published | Yes |
Bibliographical note
Copyright:Copyright 2017 Elsevier B.V., All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Food Animals
- Animal Science and Zoology
- General Immunology and Microbiology
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