Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been associated, sometimes controversially, with polymorphisms in a number of genes. Recently the butyrylcholinesterase K variant (BCHE K) allele has been shown to act in synergy with the apolipoprotein E epsilon4 (APOE epsilon4) allele to promote risk for AD. Most subsequent replicative studies have been unable to confirm these findings. We have conducted a case-control association study using a clinically well defined group of late onset AD patients (n=175) and age and sex matched control subjects (n=187) from the relatively genetically homogeneous Northern Ireland population to test this association. The BCHE genotypes of patients were found to be significantly different from controls (chi(2)=23.68, df=2, p
|Number of pages||4|
|Journal||Journal of Medical Genetics|
|Publication status||Published - 2000|
McIlroy, S. P., Crawford, V. L., Dynan, K. B., McGleenon, B. M., Vahidassr, M. D., Lawson, J. T., & Passmore, A. P. (2000). Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland. Journal of Medical Genetics, 37(3), 182-185.